This site displays the results of a literature search for compounds tested for their effects on aging related phenotypes in the nematode Caenorhabditis elegans (C. elegans). It extends the work on the terminology of aging (Fuellen et al., 2019) and on the search for aging pathways (Möller et al., 2018). For abbreviations see abbreviations.html
The collected data is expected to cover all compounds with reports on effects on healthspan that surfaced in the Pubmed search for:
(healthspan OR "healthy aging" OR fitness OR "stress resistance" OR homeostasis OR locomotion OR pumping OR "sensory perception" OR memory)
(natural OR compound OR "small molecule" OR pharmaceutical OR substance OR extract OR fraction OR fruit OR vegetable OR herb OR chemical OR plant OR "secondary metabolite")
("C. elegans" OR "Caenorhabditis elegans") AND (aging OR ageing) NOT (Review[ptyp])
We cordially invite you all to inform us about further compounds that should be included and other missing or incorrect details (contact: Nadine.Saul@HU-Berlin.de or Nadine.Saul@gmx.de). All data and source code is available at https://bitbucket.org/ibima/healthspancompoundswebsite.
This work was performed for the EU Horizon 2020 project 'Aging with elegans' (633589), by Nadine Saul <Nadine.Saul@HU-Berlin.de> at the Humboldt University of Berlin, Germany, and Steffen Möller <firstname.lastname@example.org> with Georg Fuellen, IBIMA, Rostock University Medical Center, Rostock, Germany.
To cite this work, please consider our recent publication: Saul N, Möller S, Cirulli F, Berry A, Luyten W, Fuellen G. (2021) Health and longevity studies in C. elegans: the 'healthy worm database' reveals strengths, weaknesses and gaps of test compound-based studies. Biogerontology. 22(2):215-236. doi: 10.1007/s10522-021-09913-2.
Fuellen G., Jansen L., Cohen A.A., Luyten W., Gogol M., Simm A., Saul N., Cirulli F., Berry A., Antal P., Köhling R., Wouters B., Möller S. (2019) Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways. Aging and Disease, 10(4), 2. doi: 10.14336/AD.2018.1030.
Möller S., Saul N., Cohen A., Köhling R., Sender S., Murua Escobar H., Junghanß C., Cirulli F., Berry A., Antal P., Adler P., Vilo J., Boiani M., Jansen L., Struckmann S., Barrantes I., Hamed M., Luyten W., Fuellen G. (2020) Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids Aging, 12(13):12534-12581. doi: 10.18632/aging.103514.
The web interface at the bottom of this page supports an interacive browsing of the data. To download all entries in a flat file that can be imported into R or Excel, also try: