The Healthy Worm Database

 

This site displays the results of a literature search for compounds tested for their effects on aging related phenotypes in the nematode Caenorhabditis elegans (C. elegans). It extends the work on the terminology of aging (Fuellen et al., 2019) and on the search for aging pathways (Möller et al., 2018). For abbreviations see abbreviations.html

The collected data is expected to cover all compounds with reports on effects on healthspan that surfaced in the Pubmed search for:

(healthspan OR "healthy aging" OR fitness OR "stress resistance" OR homeostasis OR locomotion OR pumping OR "sensory perception" OR memory)
AND
(natural OR compound OR "small molecule" OR pharmaceutical OR substance OR extract OR fraction OR fruit OR vegetable OR herb OR chemical OR plant OR "secondary metabolite")
AND
("C. elegans" OR "Caenorhabditis elegans") AND (aging OR ageing) NOT (Review[ptyp])

We cordially invite you all to inform us about further compounds that should be included and other missing or incorrect details (contact: Nadine.Saul@HU-Berlin.de or Nadine.Saul@gmx.de). All data and source code is available at https://bitbucket.org/ibima/healthspancompoundswebsite.

This work was performed for the EU Horizon 2020 project 'Aging with elegans' (633589), by Nadine Saul <Nadine.Saul@HU-Berlin.de> at the Humboldt University of Berlin, Germany, and Steffen Möller <steffen.moeller@uni-rostock.de> with Georg Fuellen, IBIMA, Rostock University Medical Center, Rostock, Germany.

To cite this work, please consider our recent publication: Saul N, Möller S, Cirulli F, Berry A, Luyten W, Fuellen G. (2021) Health and longevity studies in C. elegans: the 'healthy worm database' reveals strengths, weaknesses and gaps of test compound-based studies. Biogerontology. 22(2):215-236. doi: 10.1007/s10522-021-09913-2.

References:
Fuellen G., Jansen L., Cohen A.A., Luyten W., Gogol M., Simm A., Saul N., Cirulli F., Berry A., Antal P., Köhling R., Wouters B., Möller S. (2019) Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways. Aging and Disease, 10(4), 2. doi: 10.14336/AD.2018.1030.
Möller S., Saul N., Cohen A., Köhling R., Sender S., Murua Escobar H., Junghanß C., Cirulli F., Berry A., Antal P., Adler P., Vilo J., Boiani M., Jansen L., Struckmann S., Barrantes I., Hamed M., Luyten W., Fuellen G. (2020) Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids Aging, 12(13):12534-12581. doi: 10.18632/aging.103514.

The web interface at the bottom of this page supports an interacive browsing of the data. To download all entries in a flat file that can be imported into R or Excel, also try:

Search for compounds in the input field: (Please click on compounds listed below or select checkboxes before pressing enter)

- takes some 30 seconds.

IDName (PubChem)#Cond / #PhenStrains

(hide)
oxidative stress resistance
heat stress resistance
pathogen stress resistance
UV stress resistance
osmotic stress resistance
arsenite stress resistance
metal stress resistance
salt stress resistance
mean lifespan
maximum lifespan
minimum lifespan
median lifespan
survival at a given time point
ROS level
HSPs
DAF-16 to nucleus
SODs
N(6)-Carboxymethyllysine (CML)
α-synuclein
carbonylated proteins
β-Amyloid
CTLs
proteasomal activity
SKN-1 to nucleus
triglyceride / fat / lipid content
autofluorescence
GSTs
UGTs
oxygen consumption rate (OCR)
GSH level
ATP level
germline stem cells
polyQ aggregates
thiol level
GCS-1
GPDHs
GSH-PX
level of 4-HNE
AMP:ATP ratio
phosphofructokinase activity
lipase activity
hexokinase activity
pyruvate kinase activity
level of autophagy
antioxidative capacity
mitochondrial content/quality
intestinal bacteria colonization
phosphorylation level of PMK-1
MDA level
muscle integrity
activity of acetylcholinesterase
mitochondrial DNA copy number
mitochondrial ROS production
axonal HTT aggregates
axonal dystrophy
apoptotic cells
lactate level
pyruvate level
mitochondrial membrane potential
F3-isoprostane level
mitochondrial DNA (mtDNA) integrity
CYPs
acetylcholine level
SKN-1
chemotaxis
mechanical sensory / touch response
neuronal survival / integrity
aldicarb resistance
memory
D-type GABAergic motorneurons
pharyngeal pumping
locomotion in liquid media
locomotion on solid media
duration of defecation cycles
body length / growth rate
fast body movement span
fast pharyngeal pumping span
pharyngeal total span
body wave number
food consumption
number of offspring
speed of larval development
dauer formation
embryonic lethality
vertex (progeny per day)
early reproduction
onset of egg laying
late reproduction
reproductive total span
reproductive growth span
internal hatch
0 (±)-Octoclothepin maleate (11957654) 1 / 2 N2 (wild type)
1 (Iso)lappaol A (323894) 12 / 5 N2 (wild type), TJ375 {gpIs1 [hsp-16.2p::GFP]}, TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}, GR1307 [daf-16(mgDf50)], TK22 [mev-1(kn1)]
2 (R,R)-cis-Diethyl tetrahydro-2,8-chrysenediol (446849) 1 / 2 N2 (wild type)
3 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) from Curcuma longa L (65238) 2 / 5 N2 (wild type)
4 2-Ethylthio-8-methoxy-5-oxo-1-phenyl-1,5-dihydrobenzo[b][1,2,4]triazolo[1,5-g][1,6]naphthyridine-12-carbonitrile (compound 12a) 3 / 5 N2 (wild type)
5 7-Isobutylamino-2-ethylthio-6-formyl-5-oxo-1-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (compound 4c) 3 / 2 N2 (wild type)
6 7-Benzylamino-2-ethylthio-6-formyl-5-oxo-1-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (compound 4f) 4 / 5 N2 (wild type)
7 Xyloketal B (10980896) 2 / 1 N2 (wild type)
8 10-O-trans-p-Coumaroylcatalpol 9 / 9 N2 (wild type), TK22 [mev-1(kn1)], GR1307 [daf-16(mgDf50)], VC199 [sir-2.1(ok434)], TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}, NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}
9 Xyloketal, derivate 10 1 / 1 N2 (wild type)
10 Xyloketal, derivate 11 1 / 1 N2 (wild type)
11 Xyloketal, derivate 12 1 / 1 N2 (wild type)
12 Xyloketal, derivate 13 1 / 1 N2 (wild type)
13 Xyloketal, derivate 14 1 / 1 N2 (wild type)
14 Xyloketal, derivate 15 4 / 6 N2 (wild type), PS3551 [hsf-1(sy441)], CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}
15 Xyloketal, derivate 16 1 / 1 N2 (wild type)
16 Xyloketal, derivate 17 1 / 1 N2 (wild type)
17 Xyloketal, derivate 18 2 / 1 N2 (wild type)
18 18α-Glycyrrhetinic acid (73398) 23 / 14 N2 (wild type), EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]], EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]], heterozygous, EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]], EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]], heterozygous, EU40 [skn-1(zu129)/nT1[unc-?(n754) let-?]], EU40 [skn-1(zu129)/nT1[unc-?(n754) let-?]], heterozygous, CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}, LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}, unknown strain; genotype: [{[Pvha-6::UIM2-ZsProSensor]}, DR26 [daf-16(m26)], CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}, CL2331 {dvIs37 [myo-3p::GFP::A-Beta (3-42) + rol-6(su1006)]}
19 Xyloketal, derivate 19 1 / 1 N2 (wild type)
20 2,3-Dehydrosilybin A 1 / 1 N2 (wild type)
21 2,3-Dehydrosilybin A/B 9 / 14 N2 (wild type), DR26 [daf-16(m26)], CL2331 {dvIs37 [myo-3p::GFP::A-Beta (3-42) + rol-6(su1006)]}, GMC101 {dvIs100 [unc-54p::A-beta-1-42::unc-54 3'-UTR + mtl-2p::GFP]}
22 2,3-Dehydrosilybin B 1 / 1 N2 (wild type)
23 Xyloketal, derivate 2 2 / 1 N2 (wild type)
24 20-Galloyl-2,3-dehydrosilybin A/B 1 / 1 N2 (wild type)
25 Xyloketal, derivate 20 (102203087) 1 / 1 N2 (wild type)
26 Xyloketal, derivate 21 1 / 1 N2 (wild type)
27 Xyloketal, derivate 22 1 / 1 N2 (wild type)
28 Xyloketal, derivate 23 1 / 1 N2 (wild type)
29 Xyloketal, derivate 24 1 / 1 N2 (wild type)
30 Xyloketal, derivate 25 1 / 1 N2 (wild type)
31 Xyloketal, derivate 26 1 / 1 N2 (wild type)
32 Xyloketal, derivate 27 1 / 1 N2 (wild type)
33 Xyloketal, derivate 28 1 / 1 N2 (wild type)
34 Xyloketal, derivate 29 1 / 1 N2 (wild type)
35 3,4-Dichloroisocoumarin (1609) 1 / 2 N2 (wild type)
36 3,7-Dimethyl-2,3-dehydrosilybin A/B 1 / 1 N2 (wild type)
37 Xyloketal, derivate 3 1 / 1 N2 (wild type)
38 Xyloketal, derivate 30 1 / 1 N2 (wild type)
39 Xyloketal, derivate 31 1 / 1 N2 (wild type)
40 Xyloketal, derivate 32 1 / 1 N2 (wild type)
41 Xyloketal, derivate 33 1 / 1 N2 (wild type)
42 Xyloketal, derivate 34 1 / 1 N2 (wild type)
43 Xyloketal, derivate 35 1 / 1 N2 (wild type)
44 Xyloketal, derivate 36 1 / 1 N2 (wild type)
45 Xyloketal, derivate 37 1 / 1 N2 (wild type)
46 4-Caffeoylquinic acid (9798666) 1 / 1 N2 (wild type)
47 4-Phenyl-3-furoxancarbonitrile (1756) 1 / 2 N2 (wild type)
48 4-Hydroxy-E-globularinin 12 / 11 N2 (wild type), TK22 [mev-1(kn1)], GR1307 [daf-16(mgDf50)], VC199 [sir-2.1(ok434)], TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}, CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}, CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}
49 Xyloketal, derivate 4 1 / 1 N2 (wild type)
50 5-Caffeoylquinic acid (1794427) 1 / 1 N2 (wild type)
51 Xyloketal, derivate 5 2 / 1 N2 (wild type)
52 Xyloketal, derivate 6 2 / 1 N2 (wild type)
53 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (6603792) 1 / 2 N2 (wild type)
54 7-Methyl-2,3-dehydrosilybin A/B 1 / 1 N2 (wild type)
55 Xyloketal, derivate 7 2 / 1 N2 (wild type)
56 Xyloketal, derivate 8 1 / 1 N2 (wild type)
57 Xyloketal, derivate 9 1 / 1 N2 (wild type)
58 AMN082 (11698390) 1 / 2 N2 (wild type)
59 Acacetin 7-O-α-l-rhamnopyranosyl (1–2) β-D-xylopyranoside (ARX) from Premna integrifolia 16 / 13 N2 (wild type), TK22 [mev-1(kn1)], DA1116 [eat-2(ad1116)], GR1307 [daf-16(mgDf50)], VC199 [sir-2.1(ok434)], EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]], EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]], PS3551 [hsf-1(sy441)], TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}, CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}, CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}
60 Acacetin (5280442) 10 / 13 N2 (wild type), TK22 [mev-1(kn1)], CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}, CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}, NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}
61 Ag nanoparticles (particle size of 8 nm) 11 / 3 N2 (wild type)
62 Agrimonia procera, ethanol extract 30 / 6 N2 (wild type), CF1038 [daf-16(mu86)], CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}, TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}
63 Alanine (5950) 1 / 2 N2 (wild type)
64 Alanine/tyrosine mixture 1 / 2 N2 (wild type)
65 Alaskan blueberry extract 7 / 6 N2 (wild type)