Treatment | (Iso)lappaol A | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 323894 | ChEMBL | | | | | oxidative stress resistance | | | | ROS level | | | | activity / quantity / expression of HSPs | | | | translocation of DAF-16 to nucleus | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
10 µM | whole life; start: unknown | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | down | -12.13 | yes | Treatment for 72 h (start of treatment unknown); measurement via H2DCF-DA | | | | | | | | | | | | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
100 µM | whole life; start: unknown | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | down | -11.03 | yes | Treatment for 72 h (start of treatment unknown); measurement via H2DCF-DA | | | | | | | | | | | | | up-regulation of daf-16, hsf-1, and jnk-1 | | | jnk-1 and daf-16 | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
200 µM | whole life; start: unknown | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | none | | no | Treatment for 72 h (start of treatment unknown); measurement via H2DCF-DA | | | | | | | | | | | | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
10 µM | whole life; start: A1 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | up | 6.20 | no | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
100 µM | whole life; start: A1 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | up | 11.20 | yes | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
50 µM | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | up | | yes | A2; stressor: 80 µM juglone for 24 h; endpoint: survival | | | | | | | | | | | | | | | | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
100 µM | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | up | 118.07 | yes | A2; stressor: 80 µM juglone for 24 h; endpoint: survival | | | | | | | | | | | | | | | | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
200 µM | whole life; start: L4 | OP50 | NGM agar | | N2 (wild type) | 20°C | none | | no | A2; stressor: 80 µM juglone for 24 h; endpoint: survival | | | | | | | | | | | | | | | | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
100 µM | 48 h; start: unknown | OP50 | NGM agar | | TJ375 {gpIs1 [hsp-16.2p::GFP]} | 20°C | | | | | | | | | down | -34.22 | yes | pre-treated with 20 µM juglone for 24h; measured via fluorescence | | | | | | | | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
100 µM | whole life; start: L1 | OP50 | NGM agar | | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | up | | yes | A1 | | | | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
100 µM | whole life; start: A1 | OP50 | NGM agar | | GR1307 [daf-16(mgDf50)] | 20°C | | | | | | | | | | | | | | | | | down | -5.20 | no | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |
100 µM | whole life; start: A1 | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | | | | | | | | | | | | | up | 5.70 | no | | | | | | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |