Compound ID 100 (prev - next)

Name: Black tea extract (Camellia sinensis) (edit)

12 entries:

Treatment	Black tea extract (Camellia sinensis)						physiological function																healthspan biomarkers																lifespan				Transcriptome	Target	Reference
CID (PubChem)		ChEMBL					heat stress resistance				metal stress resistance				salt stress resistance				UV stress resistance				ROS level				activity / quantity / expression of SODs				activity / quantity / expression of CTLs				activity / quantity / expression of GSH-PX				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
50 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	N2 (wild type)	25°C	up	24.74	yes	A3; stressor: 35°C; endpoint: survival	up	1.50	no	A3; stressor: 35 mM MnCl2 for 30 min; endpoint: survival; similar result when compound treatment ended after stressor exposure	up	71.05	yes	A3; stressor: 500 mM NaCl for 12 h; endpoint: survival	up	19.64	yes	A3; stressor: UV-light with 2000 J/m2; endpoint: survival	down		yes	A3; measured via H2DCF-DA	none		no	A3	down	-30.00	yes	A3	up	55.90	yes	A3	up	1.07	no		up-regulation of sir-2.1, sod-3, gsh-px, and sek-1	sir-2.1	Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
100 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	N2 (wild type)	25°C	up	15.46	yes	A3; stressor: 35°C; endpoint: survival	down	-0.75	no	A3; stressor: 35 mM MnCl2 for 30 min; endpoint: survival; similar result when compound treatment ended after stressor exposure	up	88.82	yes	A3; stressor: 500 mM NaCl for 12 h; endpoint: survival	up	10.71	yes	A3; stressor: UV-light with 2000 J/m2; endpoint: survival	down		yes	A3; measured via H2DCF-DA	none		no	A3	down	-80.40	yes	A3	up	98.70	yes	A3	up	0.53	no		up-regulation of sir-2.1, sod-3, gsh-px, and sek-1		Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
200 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	N2 (wild type)	25°C	up	11.34	yes	A3; stressor: 35°C; endpoint: survival	down	-3.76	yes	A3; stressor: 35 mM MnCl2 for 30 min; endpoint: survival; no significant change when compound treatment ended after stressor exposure	up	41.12	yes	A3; stressor: 500 mM NaCl for 12 h; endpoint: survival	up	7.14	yes	A3; stressor: UV-light with 2000 J/m2; endpoint: survival	down		yes	A3; measured via H2DCF-DA	none		no	A3	down	-75.10	yes	A3	up	87.30	yes	A3	up	0.53	no		up-regulation of sir-2.1 and sek-1		Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
50 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	TK22 [mev-1(kn1)]	25°C																																	up	2.94	no				Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
100 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	TK22 [mev-1(kn1)]	25°C																																	up	5.88	no				Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
200 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	TK22 [mev-1(kn1)]	25°C																																	up	6.62	no				Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
50 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	25°C	up	3.13	no	A3; stressor: 35°C; endpoint: survival					up	39.09	yes	A3; stressor: 500 mM NaCl for 12 h; endpoint: survival	none		no	A3; stressor: UV-light with 2000 J/m2; endpoint: survival																							Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
100 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	25°C	up	2.08	no	A3; stressor: 35°C; endpoint: survival					up	70.68	yes	A3; stressor: 500 mM NaCl for 12 h; endpoint: survival	up	1.79	no	A3; stressor: UV-light with 2000 J/m2; endpoint: survival																							Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.
200 mg/L	whole life; start: A1	OP50, UV-inactivated	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	25°C	up	1.04	no	A3; stressor: 35°C; endpoint: survival					up	43.97	yes	A3; stressor: 500 mM NaCl for 12 h; endpoint: survival	down	-1.79	no	A3; stressor: UV-light with 2000 J/m2; endpoint: survival																							Xiong LG, Huang JA, Li J, Yu PH, Xiong Z, Zhang JW, Gong YS, Liu ZH, Chen JH (2014) Black tea increased survival of Caenorhabditis elegans under stress. J Agric Food Chem 62, 11163-11169.