Treatment | Bletilla striata polysaccharide | physical function | reproductive function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | locomotion in liquid media | number of offspring | vertex (progeny per day) | heat stress resistance | oxidative stress resistance | mean lifespan | |||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
10 µg/ml | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | up | no | Zhang Y, Lv T, Li M, Xue T, Liu H, Zhang W, Ding X, Zhuang Z (2015) Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans. Pharmacogn Mag 11, 449-454. | ||||||||||||||||||||||||||||
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | up | yes | A4, A8, A12, A16, and A20; Head thrash and body bend | none | no | none | no | up | yes | A2; stressor: 35°C; endpoint: survival | up | yes | A2; stressor: paraquat; endpoint: survival | up | yes | down-regulation of age-1 and hcf-1 | insulin/IGF signaling pathway | Zhang Y, Lv T, Li M, Xue T, Liu H, Zhang W, Ding X, Zhuang Z (2015) Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans. Pharmacogn Mag 11, 449-454. | |||||||||||||
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | up | no | Zhang Y, Lv T, Li M, Xue T, Liu H, Zhang W, Ding X, Zhuang Z (2015) Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans. Pharmacogn Mag 11, 449-454. | ||||||||||||||||||||||||||||
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | unknown strain [daf-16 deletion mutant] | 20°C | none | no | Zhang Y, Lv T, Li M, Xue T, Liu H, Zhang W, Ding X, Zhuang Z (2015) Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans. Pharmacogn Mag 11, 449-454. |