Compound ID 106 (prev - next)

Name: Blueberry (Vaccinium angustifolium) polyphenol fraction (135310604) (edit)

17 entries:

Treatment	Blueberry (Vaccinium angustifolium) polyphenol fraction						physical function				physiological function								healthspan biomarkers												lifespan								Target	Reference
CID (PubChem)	135310604	ChEMBL					pharyngeal pumping				heat stress resistance				oxidative stress resistance				autofluorescence (age pigment / lipofuscin)				activity / quantity / expression of HSPs				level of 4-HNE				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
67 µg/ml	whole life; start: A1	OP50	NGM agar		BA17 [fem-1(hc17)]	25°C					up		yes	A5; Stressor: 35°C for 16h																	up									Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		BA17 [fem-1(hc17)]	25°C	up		yes	A8 & A10	up		yes	A5; Stressor: 35°C for 16h	none	none	no	Stressor: 10 mM Paraquat or different concentrations of hydrogen peroxide	down	-20	yes	A16	down		yes	A4; HSP-12.6, HSP-16.1, HSP-16.49, HSP-70; no significant effects at A1 and L4	down		yes	A14	up	28.00	yes		up	14	yes	25°C; Strain fem-1(hc17) was used	osr-1/unc-43/sek-1 pathway	Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		BA17 [fem-1(hc17)]	20°C																									up	16.00	yes							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		BA17 [fem-1(hc17)]	15°C																									down	-3.00	no							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
67 µg/ml	whole life; start: A1	OP50	NGM agar	Ampicillin	BA17 [fem-1(hc17)]	25°C					up		yes	Similar values to tests without ampicillin																										Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar	Ampicillin	BA17 [fem-1(hc17)]	25°C					up		yes	Similar values to tests without ampicillin																	up	3.43	no	Compared to Ampicillin treatment without polyphenol fraction						Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		GR1307 [daf-16(mgDf50)]	25°C																									up	21.00	yes							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar	Ampicillin	GR1307 [daf-16(mgDf50)]	25°C																									up	15.75	yes	Compared to Ampicillin treatment without polyphenol fraction						Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		TK22 [mev-1(kn1)]	25°C																									down	-5.00	no							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		VC199 [sir-2.1(ok434)]	25°C																									up	30.00	yes							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	25°C																									up	32.00	yes							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		AM1 [osr-1(rm1)]	25°C																									down	-4.00	no							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		AU1 [sek-1(ag1)]	25°C																									down	-7.00	no							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		MT2605 [unc-43(n498n1186)]	25°C																									down	-2.00	no							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.