Compound ID 108   (prev - next)

Name: Brazilin (from Caesalpinia sappan) (73384) (edit)

9 entries:
TreatmentBrazilin (from Caesalpinia sappan)physical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)73384ChEMBLpharyngeal pumpinglocomotion on solid mediabody length / growth ratenumber of offspringheat stress resistanceoxidative stress resistanceosmotic stress resistanceROS levelactivity / quantity / expression of HSPsactivity / quantity / expression of SODsmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
50 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)20°CnonenoA4 and A8up4.40yesA8; no significant changes at A4nonenononenoup16.70yesA4; stressor: 36°C; endpoint: mean survival; also increased maximum lifespanup46.40yesA7; stressor: 900 µM juglone; endpoint: mean lifespan; also increased maximum lifespanupnoA3; stressor: 500 mM NaCl for 12 h; endpoint: survivaldownyesA4; pre-exposed to 50 µM juglone for 2 h; measured via H2DCF-DAupyesA5; activity of SODup11.30yesup11.76n.d.HSP-16.2 and SOD-3Lee EB, Xing MM, Kim DK (2017) Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. Arch Pharm Res 40, 825-835.
100 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)20°CvariablenoA4 and A8up5.90yesA8; no significant changes at A4nonenodownnoup32.60yesA4; stressor: 36°C; endpoint: mean survival; also increased maximum lifespanup97.10yesA7; stressor: 900 µM juglone; endpoint: mean lifespan; also increased maximum lifespanupyesA3; stressor: 500 mM NaCl for 12 h; endpoint: survivaldown-10.40yesA4; pre-exposed to 50 µM juglone for 2 h; measured via H2DCF-DAupyesA5; activity of SODup17.90yesup17.65n.d.Lee EB, Xing MM, Kim DK (2017) Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. Arch Pharm Res 40, 825-835.
50 µMwhole life; start: egg stageOP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA3; expression of sod-3; measured via fluorescenceLee EB, Xing MM, Kim DK (2017) Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. Arch Pharm Res 40, 825-835.
100 µMwhole life; start: egg stageOP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cup19.30yesA3; expression of sod-3; measured via fluorescenceLee EB, Xing MM, Kim DK (2017) Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. Arch Pharm Res 40, 825-835.
50 µMwhole life; start: egg stageOP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CupyesA3; pre-exposed to 36 °C for 2 h; measured via fluorescenceLee EB, Xing MM, Kim DK (2017) Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. Arch Pharm Res 40, 825-835.
100 µMwhole life; start: egg stageOP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°Cup36.00yesA3; pre-exposed to 36 °C for 2 h; measured via fluorescenceLee EB, Xing MM, Kim DK (2017) Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. Arch Pharm Res 40, 825-835.