Compound ID 116 (prev - next)

Name: Calycosin (5280448) (edit)

15 entries:

Treatment	Calycosin						physiological function								healthspan biomarkers												lifespan				Transcriptome	Target	Reference
CID (PubChem)	5280448	ChEMBL					heat stress resistance				oxidative stress resistance				ROS level				translocation of SKN-1 to nucleus				translocation of DAF-16 to nucleus				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
50 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																					up	6.24	yes				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																					up	15.64	yes				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A3; stressor: 36°C for 4 h; endpoint: mean lifespan	up		yes	A3; stressor: 10 mM paraquat; endpoint: mean lifespan	down		yes	A3; 37°C during measurement; measured via H2DCF-DA									up	24.86	yes		up-regulation of daf-16, sod-3,hsp.16.2, and ctl-1	insulin-signaling pathway, daf-2, age-1, daf-16, sod-3,hsp.16.2, and ctl-1	Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
400 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																					up	17.80	yes				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	GR1307 [daf-16(mgDf50)]	20°C																					none		no				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	CB1370 [daf-2(e1370)]	20°C																					up	0.82	no				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	TJ1052 [age-1(hx546)]	20°C																					up	1.04	no				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	DA1116 [eat-2(ad1116)]	20°C																					up	7.41	yes				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	MT2605 [unc-43(n498n1186)]	20°C																					up	20.85	yes				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	FUDR	EU35 [skn-1(zu169)/nT1 [unc-?(n754) let-?]]	20°C																					up	34.34	yes				Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	2 h; start: L4	OP50, heat-inactivated	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																	up	178.79	yes	L4							Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.
200 µM	2 h; start: L4	OP50, heat-inactivated	NGM agar		unknown strain [SKN-1::GFP]	20°C													none		no	L4											Lu L, Zhao X, Zhang J, Li M, Qi Y, Zhou L (2017) Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. J Biosci Bioeng 124, 1-7.