Compound ID 119   (prev - next)

Name: Carqueja hydroalcoholic extract (edit)

34 entries:
TreatmentCarqueja hydroalcoholic extractphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLpharyngeal pumpinglocomotion on solid mediabody length / growth ratenumber of offspringvertex (progeny per day)oxidative stress resistanceproteasomal activityROS levelactivity / quantity / expression of HSPsactivity / quantity / expression of HSPstriglyceride / fat / lipid contentactivity / quantity / expression of SODsactivity / quantity / expression of GCS-1activity / quantity / expression of GSTsmedian lifespanmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
0.5 mg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cdown-7.84noL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
5 mg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cdown-2.21noL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°CnonenoL4nonenoL4nonenononenoup27.08yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalupyesL4downyesL4; measured via H2DCF-DA at 37°C; similar change when pre-exposed to 5 mM H2O2downyesL4; measured via Nile RedHSP-16.2 and HSP-4Paiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
0.5 mg/mlwhole life; start: L1OP50NGM agarKanamycinN2 (wild type)20°Cup1.75noL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
5 mg/mlwhole life; start: L1OP50NGM agarKanamycinN2 (wild type)20°Cdown-16.94yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarKanamycinN2 (wild type)20°Cup8.96yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1HT115 (DE3)NGM agarampicillin, IPTGN2 (wild type)20°Cup7.75yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1HT115 (DE3) with RNAi-vector against skn-1 & daf-16NGM agarampicillin, IPTGN2 (wild type)20°Cup28.08yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
0.5 mg/mlwhole life; start: L1OP50NGM agarBA17 [fem-1(hc17)]25°Cup9.09n.d.up5.04noup1.10n.d.Paiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
5 mg/mlwhole life; start: L1OP50NGM agarBA17 [fem-1(hc17)]25°Cup18.18n.d.down-0.08noup7.73n.d.Paiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarBA17 [fem-1(hc17)]25°Cup18.18n.d.up0.92noup1.66n.d.Paiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]20°Cup47.69yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarCF1038 [daf-16(mu86)]20°Cup21.95yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarAU3 [nsy-1(ag3)]20°Cup15.79yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarKanamycinAU3 [nsy-1(ag3)]20°Cup13.63yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarKU4 [sek-1(km4)]20°Cup26.76yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarVC8 [jnk-1(gk7)]20°Cup10yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarKanamycinVC8 [jnk-1(gk7)]20°Cup6.27yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarAM1 [osr-1(rm1)]20°Cup15.48yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarKU25 [pmk-1(km25)]20°Cup19.18yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarMH37 [mpk-1(ku1); unc-32(e189)]20°Cup24yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarKanamycinMH37 [mpk-1(ku1); unc-32(e189)]20°Cup13.77yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarMT2605 [unc-43(n498n1186)]20°Cup22.35yesL4; stressor: 7.5 mM tert-butyl hydrogen peroxide; endpoint: survivalPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarLD1171 {ldIs3 [gcs-1p::GFP + rol-6(su1006)]}20°CdownyesL4; expression of gcs-1; measured via fluorescence; pre-exposed to 7.5 mM tert-butyl hydrogen peroxide for 1 h; no significant change without pre-exposurePaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
5 mg/mlwhole life; start: L1OP50NGM agarCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CdownnoL4; expression of gst-4; measured via fluorescence; pre-exposed to 7.5 mM tert-butyl hydrogen peroxide for 1 h; no change without pre-exposurePaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CupyesL4; expression of gst-4; measured via fluorescence; no significant change when pre-exposed to 7.5 mM tert-butyl hydrogen peroxide for 1 hPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CdownyesL4; expression of sod-3; measured via fluorescence; no significant change when pre-exposed to 7.5 mM tert-butyl hydrogen peroxide for 1 hPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CvariableyesL4; expression of hsp-16.2; measured via fluorescence; increased when pre-exposed to 35°C for 1 h; decreased without pre-exposurePaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarSJ4005 {zcIs4 [hsp-4::GFP]}20°CupyesL4; expression of hsp-16.2; measured via fluorescence; no change when pre-exposed to 35°C for 1 hPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}25°CupyesL3/L4; ratio of non-paralyzed and paralyzed nematodesPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.
50 mg/mlwhole life; start: L1OP50NGM agarKanamycinCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}25°CupyesL3/L4; ratio of non-paralyzed and paralyzed nematodesPaiva FA, Bonomo Lde F, Boasquivis PF, de Paula IT, Guerra JF, Leal WM, Silva ME, Pedrosa ML, Oliveira Rde P (2015) Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2015:740162.