Treatment | Catalpol | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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CID (PubChem) | 91520 | ChEMBL | pharyngeal pumping | locomotion on solid media | body length / growth rate | number of offspring | quantity of early reproduction | heat stress resistance | oxidative stress resistance | osmotic stress resistance | autofluorescence (age pigment / lipofuscin) | ROS level | activity / quantity / expression of SODs | activity / quantity / expression of CTLs | translocation of DAF-16 to nucleus | mean lifespan | maximum lifespan | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
6.25 µM | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 22°C | none | no | A4 | up | no | A7; totaltravel distance | none | no | A4 | none | no | none | no | none | n.d. | A4; stressor: 36°C, endpoint: survival | up | n.d. | A4; stressor: 60 mM paraquat; endpoint: survival | none | no | A4; stressor: 500 mM NaCl for 12 h; endpoint: survival | down | no | A4; measured via H2DCF-DA | none | no | A5; SOD activity | up | yes | A5; catalase activity | up | no | up | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | ||||||||||||||||||||||||||||||
12.5 µM | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 22°C | down | no | A4 | up | no | A7; totaltravel distance | none | no | A4 | none | no | none | no | up | n.d. | A4; stressor: 36°C, endpoint: survival | up | n.d. | A4; stressor: 60 mM paraquat; endpoint: survival | none | no | A4; stressor: 500 mM NaCl for 12 h; endpoint: survival | down | yes | A4; measured via H2DCF-DA | up | yes | A5; SOD activity | up | yes | A5; catalase activity | up | yes | up | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | ||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | N2 (wild type) | 22°C | down | yes | A4 | up | 30.00 | yes | A7; totaltravel distance | none | no | A4 | none | no | down | yes | up | n.d. | A4; stressor: 36°C, endpoint: survival | up | n.d. | A4; stressor: 60 mM paraquat; endpoint: survival | none | no | A4; stressor: 500 mM NaCl for 12 h; endpoint: survival | down | -13.25 | yes | A7; green fluorescence | down | -44.57 | yes | A4; measured via H2DCF-DA | up | 50.10 | yes | A5; SOD activity | up | 46.40 | yes | A5; catalase activity | up | n.d. | A4 | up | 28.50 | yes | up | 50.00 | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | |||||||||||||||||
6.25 µM | whole life; start: A7 | OP50 | NGM agar | N2 (wild type) | 22°C | up | no | none | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
12.5 µM | whole life; start: A7 | OP50 | NGM agar | N2 (wild type) | 22°C | up | no | up | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: A7 | OP50 | NGM agar | N2 (wild type) | 22°C | up | yes | up | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 22°C | up | yes | A3; expression of sod-3; pre-exposed to 36°C for 2 h | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]] | 22°C | down | -0.80 | no | down | -5.00 | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | VC199 [sir-2.1(ok434)] | 22°C | up | 10.30 | yes | up | 21.05 | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | GR1307 [daf-16(mgDf50)] | 22°C | up | 0.90 | no | none | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | DR1572 [daf-2(e1368)] | 22°C | none | no | down | -3.70 | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | TJ1052 [age-1(hx546)] | 22°C | up | 3.40 | no | up | 3.57 | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
25 µM | whole life; start: egg stage | OP50 | NGM agar | FK171 [mek-1(ks54)] | 22°C | down | -5.56 | n.d. | Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. | no | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
150 µg/ml | whole life; start: n.d. | OP50 | NGM agar | N2 (wild type) | 20°C | up | n.d. | A4 | up | n.d. | A7 | up | n.d. | A4 | none | no | up | n.d. | A4; stressor: 37°C; endpoint: mean survival | up | n.d. | A4; stressor: H2O2; endpoint: mean survival | down | n.d. | A10; green fluorescence | up | 7.3 | no | Zeng L, Sun C, Pei Z, Yun T, Fan S, Long S, Wu T, Chen Z, Yang Z, Xu F (2019) Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO. Biogerontology 20, 665-676. | no |