Compound ID 121   (prev - next)

Name: Catalpol (91520) (edit)

17 entries:
TreatmentCatalpolphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)91520ChEMBLpharyngeal pumpinglocomotion on solid mediabody length / growth ratenumber of offspringquantity of early reproductionheat stress resistanceoxidative stress resistanceosmotic stress resistanceautofluorescence (age pigment / lipofuscin)ROS levelactivity / quantity / expression of SODsactivity / quantity / expression of CTLstranslocation of DAF-16 to nucleusmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
6.25 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)22°CnonenoA4upnoA7; totaltravel distancenonenoA4nonenononenononen.d.A4; stressor: 36°C, endpoint: survivalupn.d.A4; stressor: 60 mM paraquat; endpoint: survivalnonenoA4; stressor: 500 mM NaCl for 12 h; endpoint: survivaldownnoA4; measured via H2DCF-DAnonenoA5; SOD activityupyesA5; catalase activityupnoupn.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
12.5 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)22°CdownnoA4upnoA7; totaltravel distancenonenoA4nonenononenoupn.d.A4; stressor: 36°C, endpoint: survivalupn.d.A4; stressor: 60 mM paraquat; endpoint: survivalnonenoA4; stressor: 500 mM NaCl for 12 h; endpoint: survivaldownyesA4; measured via H2DCF-DAupyesA5; SOD activityupyesA5; catalase activityupyesupn.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)22°CdownyesA4up30.00yesA7; totaltravel distancenonenoA4nonenodownyesupn.d.A4; stressor: 36°C, endpoint: survivalupn.d.A4; stressor: 60 mM paraquat; endpoint: survivalnonenoA4; stressor: 500 mM NaCl for 12 h; endpoint: survivaldown-13.25yesA7; green fluorescencedown-44.57yesA4; measured via H2DCF-DAup50.10yesA5; SOD activityup46.40yesA5; catalase activityupn.d.A4up28.50yesup50.00n.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
6.25 µMwhole life; start: A7OP50NGM agarN2 (wild type)22°Cupnononen.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
12.5 µMwhole life; start: A7OP50NGM agarN2 (wild type)22°Cupnoupn.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: A7OP50NGM agarN2 (wild type)22°Cupyesupn.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}22°CupyesA3; expression of sod-3; pre-exposed to 36°C for 2 hSeo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarEU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]22°Cdown-0.80nodown-5.00n.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarVC199 [sir-2.1(ok434)]22°Cup10.30yesup21.05n.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarGR1307 [daf-16(mgDf50)]22°Cup0.90nononen.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarDR1572 [daf-2(e1368)]22°Cnonenodown-3.70n.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarTJ1052 [age-1(hx546)]22°Cup3.40noup3.57n.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
25 µMwhole life; start: egg stageOP50NGM agarFK171 [mek-1(ks54)]22°Cdown-5.56n.d.Seo HW, Cheon SM, Lee MH, Kim HJ, Jeon H, Cha DS (2015) Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans. Evid Based Complement Alternat Med 2015, 524878. no
150 µg/mlwhole life; start: n.d.OP50NGM agarN2 (wild type)20°Cupn.d.A4upn.d.A7upn.d.A4nonenoupn.d.A4; stressor: 37°C; endpoint: mean survivalupn.d.A4; stressor: H2O2; endpoint: mean survivaldownn.d.A10; green fluorescenceup7.3noZeng L, Sun C, Pei Z, Yun T, Fan S, Long S, Wu T, Chen Z, Yang Z, Xu F (2019) Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO. Biogerontology 20, 665-676. no