Treatment | (±) Catechin | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 9064 | ChEMBL | CHEMBL206452 | | | | pharyngeal pumping | | | | body length / growth rate | | | | number of offspring | | | | vertex (progeny per day) | | | | quantity of early reproduction | | | | onset of egg laying | | | | heat stress resistance | | | | oxidative stress resistance | | | | triglyceride / fat / lipid content | | | | antioxidative capacity | | | | median lifespan | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
100 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 11.24 | n.d. | | up | 8.39 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | up | | yes | A3, A6 & A9 | down | -6,35 | yes | A6 | up | 3.6 | no | | none | | no | | | | | | | | | | up | 8.6 | yes | A6; Stressor: 35°C for 8 h; endpoint: survival | up | 17.33 | yes | A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival | | | | | | | | | up | 13.27 | n.d. | | up | 8.87 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
300 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 9.56 | n.d. | | up | 5.86 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | start: parental generation; stop: A6 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 2.81 | n.d. | | up | 1.13 | no | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 15°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 14.19 | n.d. | | up | 14.68 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 23°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 8.95 | n.d. | | up | 10.92 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 until A6; from A6: OP50, heat-inactivated | NGM agar | Ampicillin | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 5.88 | n.d. | | up | 7.81 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | TJ1052 [age-1(hx546)] | 23°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 6.19 | n.d. | | up | 11.05 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | VC204 [akt-2(ok393)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 4.15 | n.d. | | up | 2.79 | no | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | DR20 [daf-12(m20)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 6.05 | n.d. | | up | 9.49 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | GR1307 [daf-16(mgDf50)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 6.12 | n.d. | | up | 6.21 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | VC8 [jnk-1(gk7)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 5.20 | n.d. | | up | 5.59 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 1.30 | n.d. | | up | 0.7 | no | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | AE501 [nhr-8(ok186)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 4.20 | n.d. | | up | 1.98 | no | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | AM1 [osr-1(rm1)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 17.64 | n.d. | | up | 13.7 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | VC199 [sir-2.1(ok434)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 4.50 | n.d. | | up | 5.88 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 2.48 | n.d. | | up | 11.73 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | MT2605 [unc-43(n498n1186)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 3.60 | n.d. | | up | 3.99 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | DR1567 [daf-2(m577)] | 23°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 3.95 | n.d. | | up | 0.21 | no | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | AU1 [sek-1(ag1)] | 15°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 10.84 | n.d. | | up | 11.16 | yes | | | | | | Saul N, Pietsch K, Menzel R, Stürzenbaum SR, Steinberg CEW (2009): Catechin induced longevity in C. elegans: From key regulator genes to disposable soma. Mech Ageing Dev. 130, 477-486 | no |
100 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | A6; Stressor: 35°C for 8 h; endpoint: survival | up | | no | A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival | | | | | | | | | | | | | up | | yes | | | | | | Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720. | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | up | | A3, A6, and A9 | | down | | yes | A6 | none | | no | | | | | | none | | no | | none | | yes | | up | | yes | A6; Stressor: 35°C for 8 h; endpoint: survival | up | | yes | A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival | down | | no | A1 | none | | no | A1 | | | | | up | | yes | | | | | | Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720. | no |
300 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | up | | no | A6; Stressor: 35°C for 8 h; endpoint: survival | up | | yes | A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival | | | | | | | | | | | | | up | | yes | | | | | | Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720. | no |
400 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | up | | no | A6; Stressor: 35°C for 8 h; endpoint: survival | up | | yes | A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival | | | | | | | | | | | | | up | | yes | | | | | | Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720. | no |
800 µM | whole life; start: parental generation | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | up | | no | A6; Stressor: 35°C for 8 h; endpoint: survival | up | | yes | A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival | | | | | | | | | | | | | up | | yes | | | | | | Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720. | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | TK22 [mev-1(kn1)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720. | no |
200 µM | whole life; start: parental generation | OP50 | NGM agar | | DA465 [eat-2(ad465)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720. | no |