Treatment | Cerium oxide nanoparticles | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 73963 | ChEMBL | | | | | body length / growth rate | | | | number of offspring | | | | vertex (progeny per day) | | | | heat stress resistance | | | | activity / quantity / expression of HSPs | | | | activity / quantity / expression of GSTs | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
0.172 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
1.72 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | GST-4 and HSP-4 | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
17.21 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | none | | no | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
0.172 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | none | | no | A2, A4, and A6 | down | | yes | | down | | yes | | down | | no | A3; stressor: 35°C for 8 h; endpoint: survival | | | | | up | | yes | A6; no significant change at A2 and A4 | | | | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
1.72 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | down | | yes | A2; no significant change at A6 and A4 | down | | yes | | down | | yes | | down | | no | A3; stressor: 35°C for 8 h; endpoint: survival | | | | | up | | yes | A2 and A6; no significant change at A4 | | | | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
17.21 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | down | | yes | A2; no significant change at A6 and A4 | down | | yes | | down | | yes | | none | | no | A3; stressor: 35°C for 8 h; endpoint: survival | | | | | up | | yes | A2 and A6; no significant change at A4 | | | | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
0.172 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | SJ4005 {zcIs4 [hsp-4::GFP]} | 20°C | none | | no | A2, A4, and A6 | down | | no | | down | | no | | down | | yes | A3; stressor: 35°C for 8 h; endpoint: survival | up | | yes | A2; no significant change at A4 and A6 | | | | | | | | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
1.72 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | SJ4005 {zcIs4 [hsp-4::GFP]} | 20°C | down | | yes | A6; no significant change at A2 and A4 | down | | no | | down | | no | | down | | yes | A3; stressor: 35°C for 8 h; endpoint: survival | up | | yes | A2 and A6; no significant change at A4 | | | | | | | | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |
17.21 μg/mL | whole life; start: L4 | OP50-1 | NGM agar | | SJ4005 {zcIs4 [hsp-4::GFP]} | 20°C | down | | yes | A6; no significant change at A2 and A4 | down | | no | | down | | no | | down | | yes | A3; stressor: 35°C for 8 h; endpoint: survival | up | | yes | A2, A4, and A6 | | | | | | | | | | | | | Rogers S, Rice KM, Manne ND, Shokuhfar T, He K, Selvaraj V, Blough ER (2015) Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans. SAGE Open Med 3, 2050312115575387. | |