Compound ID 125 (prev - next)

Name: Chlorogenic acid (1794427) (edit)

30 entries:

Treatment	Chlorogenic acid						physical function				reproductive function				physiological function												healthspan biomarkers				lifespan								Transcriptome	Target	Reference
CID (PubChem)	1794427	ChEMBL	CHEMBL284616				fast body movement span				quantity of dauer formation				heat stress resistance				oxidative stress resistance				pathogen stress resistance				translocation of DAF-16 to nucleus				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
67 µg/ml	whole life; start: A1	OP50	NGM agar		BA17 [fem-1(hc17)]	25°C									none		no	A5; Stressor: 35°C for 16h													none	none	no								Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
200 µg/ml	whole life; start: A1	OP50	NGM agar		BA17 [fem-1(hc17)]	25°C									none		no	A5; Stressor: 35°C for 16h																							Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5, 59-68.
5 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									variable		no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
10 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	6.83	no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up		yes						up	28.00	yes	A5; Stressor: 35°C; endpoint: mean lifespan	up	20.00	yes	A1; stressor: 5 mM paraquat; endpoint: mean lifespan									up	20.10	yes		up	14.29	n.d.				Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar		N2 (wild type)	20°C					up	153.22	yes	eggs were exposed to 27°C																									up-regulation of immune-related genes: F35E12.5, F08G5.6, F55G11.4, K08D8.5, C23G10.1, Y22F5A.5, T24B8.5, F56D6.2, C03A7.4, F28D1.5, F59B1.8, K02F3.4, and Y43F8B.2; up-regulation of skn-1, hif-1, gst-4, f22b5.4, nhr-57, sod-3, dod-3, hsp-12.6, hsp-16.1, and hsp-16.2	IIS pathway, DAF-16, SKN-1, HIF-1, and HSF-1	Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
500 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	16.07	variable								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
2000 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	6.1	no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	25°C																	up	8.6	yes	L4/A1; stressor: Pseudomonas aeruginosa infection; endpoint: mean lifespan					up	25.10	yes		up	25.00	n.d.				Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
500 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	25°C																									up	11.35	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
2000 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	25°C																									up	6.45	variable								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50, heat-inactivated	NGM agar	FUDR	N2 (wild type)	20°C																									up	27.10	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	DA1116 [eat-2(ad1116)]	20°C																									up	23.30	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	VC199 [sir-2.1(ok434)]	20°C																									up	23.25	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	MQ887 [isp-1(qm150)]	20°C																									up	18.70	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	CB4876 [clk-1(e2519)]	20°C																									up	8.40	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C																									up	12.10	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	PS3551 [hsf-1(sy441)]	20°C																									up	8.30	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	CB1370 [daf-2(e1370)]	20°C									down		no	A5; Stressor: 35°C; endpoint: mean lifespan													down	-5.88	no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	CF1038 [daf-16(mu86)]	20°C									down		no	A5; Stressor: 35°C; endpoint: mean lifespan													variable		no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	12 h; start: L4	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C																					up		yes	A1											Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	JT9609 [pdk-1(sa680)]	20°C									up	5.90	yes														up	6.60	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	RB759 [akt-1(ok525)]	20°C									none		no	A5; Stressor: 35°C; endpoint: mean lifespan													down	-5.24	no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	VC204 [akt-2(ok393)]	20°C																									variable		no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	VC345 [sgk-1(ok538)]	20°C																									down	-0.85	no								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	CF1903 [glp-1(e2144)]	25°C																									up	15.50	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.
50 µM	whole life; start: L1	OP50	NGM agar	FUDR	ZG31 [hif-1(ia4)]	20°C																									up	5.00	yes								Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR (2017) Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. J Gerontol A Biol Sci Med Sci 72, 464-472.