Compound ID 130 (prev - next)

Name: Citalopram (2771) (edit)

8 entries:

Treatment	Citalopram						cognitive function				healthspan biomarkers				Reference
CID (PubChem)	2771	ChEMBL					mechanical sensory / touch response				translocation of DAF-16 to nucleus
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
10 µM	whole life; start: egg stage	OP50	NGM agar		CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	20°C	none			paralysis assay with daily measurements of Alzheimer disease model					Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
100 µM	whole life; start: egg stage	OP50	NGM agar		CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	20°C	none			paralysis assay with daily measurements of Alzheimer disease model					Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µM	whole life; start: egg stage	OP50	NGM agar		CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	20°C	none			paralysis assay with daily measurements of Alzheimer disease model					Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
2000 µM	whole life; start: egg stage	OP50	NGM agar		CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	20°C	none			paralysis assay with daily measurements of Alzheimer disease model					Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
2000 µM	whole life; start: egg stage	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C					none		no		Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.