Compound ID 134   (prev - next)

Name: Cranberry extract (Vaccinium macrocarpon) (135331993) (edit)

29 entries:
TreatmentCranberry extract (Vaccinium macrocarpon)cognitive functionphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)135331993ChEMBLmemorylocomotion on solid medianumber of offspringheat stress resistanceoxidative stress resistancepathogen stress resistanceosmotic stress resistanceosmotic stress resistanceUV stress resistanceROS levelquantity of β-Amyloidtranslocation of DAF-16 to nucleusmedian lifespanmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
2 mg/mlstart: egg stage; stop: A2OP50NGM agarFUDRN2 (wild type)25°CnonenoA2; endpoint: body bends per minuteupyesA2; Stressor: 37 °C for 1.5 h; endpoint: mean lifespanup11.50yesA2; Stressor: Vibrio cholerae; endpoint: mean lifespanupn.d.up12.80yesChange of remaining lifespan after stop of treatment = 11.10 %Guha S, Natarajan O, Murbach CG, Dinh J, Wilson EC, Cao M, Zou S, Dong Y (2014) Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients 6, 911-921.
2 mg/mlstart: egg stage; stop: A6OP50NGM agarFUDRN2 (wild type)25°CnonenoA6; endpoint: body bends per minuteup61.30yesA6; Stressor: 37 °C for 1.5 h; endpoint: mean lifespanup23.30yesA6; Stressor: Vibrio cholerae; endpoint: mean lifespanupn.d.up14.40yesChange of remaining lifespan after stop of treatment = 32.70 %Guha S, Natarajan O, Murbach CG, Dinh J, Wilson EC, Cao M, Zou S, Dong Y (2014) Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients 6, 911-921.
2 mg/mlstart: egg stage; stop: A10OP50NGM agarFUDRN2 (wild type)25°CupyesA10; endpoint: body bends per minuteup76.50yesA10; Stressor: 37 °C for 1.5 h; endpoint: mean lifespanup25.30yesA10; Stressor: Vibrio cholerae; endpoint: mean lifespanupn.d.up20.00yesChange of remaining lifespan after stop of treatment = 80.80 %Guha S, Natarajan O, Murbach CG, Dinh J, Wilson EC, Cao M, Zou S, Dong Y (2014) Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients 6, 911-921.
2 mg/mlstart: L4; stop: A2OP50NGM agarFUDRN2 (wild type)25°CdownnoA2; endpoint: body bends per minuteupyesA2; Stressor: 37 °C for 1.5 h; endpoint: mean lifespannonenoA2; Stressor: Vibrio cholerae; endpoint: mean lifespanupn.d.up8.20yespercentage values correspond to the remaining lifespan after stop of treatmentGuha S, Natarajan O, Murbach CG, Dinh J, Wilson EC, Cao M, Zou S, Dong Y (2014) Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients 6, 911-921.
2 mg/mlstart: L4; stop: A6OP50NGM agarFUDRN2 (wild type)25°CnonenoA6; endpoint: body bends per minuteup9.30yesA6; Stressor: 37 °C for 1.5 h; endpoint: mean lifespannonenoA6; Stressor: Vibrio cholerae; endpoint: mean lifespanupn.d.up21.20yespercentage values correspond to the remaining lifespan after stop of treatmentGuha S, Natarajan O, Murbach CG, Dinh J, Wilson EC, Cao M, Zou S, Dong Y (2014) Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients 6, 911-921.
2 mg/mlstart: L4; stop: A10OP50NGM agarFUDRN2 (wild type)25°CnonenoA10; endpoint: body bends per minuteup33.80yesA10; Stressor: 37 °C for 1.5 h; endpoint: mean lifespannonenoA10; Stressor: Vibrio cholerae; endpoint: mean lifespanupn.d.up69.70yespercentage values correspond to the remaining lifespan after stop of treatmentGuha S, Natarajan O, Murbach CG, Dinh J, Wilson EC, Cao M, Zou S, Dong Y (2014) Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients 6, 911-921.
0.2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRN2 (wild type)25°Cup7.69n.d.up12.37noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRN2 (wild type)25°Cup25n.d.up25.60yesGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
10 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRN2 (wild type)25°Cdown-20n.d.down-12.67noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: 2 generations beforeOP50NGM agarN2 (wild type)25°Cdown-20.83noL4/A1; endpoint: body bends per minuteupyesL4/A1; stressor: 37°C for 3.5 h; endpoint: survivalnonenoL4/A1; stressor: 5 mM paraquat; endpoint: survivaldownyesL4/A1; stressor: 300 or 500 mM NaCl for 10 min; endpoint: motilitydownyesL4/A1; stressor: 500 mM NaCl; endpoint: survivalnonenoL4/A1; stressor: 0.05 J/cm2 for 20 s; endpoint: survivalnonenoA1 and A4; pre-exposed to 5 mM paraquatGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarN2 (wild type)25°Cdown-14.19noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarN2 (wild type)20°Cup16.22noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarN2 (wild type)16°Cdown-2.35noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRGR1307 [daf-16(mgDf50)]25°Cnonen.d.up05.04noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRVC199 [sir-2.1(ok434)]25°Cup18.75n.d.up19.25yesGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRAM1 [osr-1(rm1)]25°Cnonen.d.down-6.06noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRAU1 [sek-1(ag1)]25°Cup10.71n.d.up10.71noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRMT2605 [unc-43(n498n1186)]25°Cup6.67n.d.up6.48noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRCB1370 [daf-2(e1370)]25°Cup3.57n.d.up4.58noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRVC8 [jnk-1(gk7)]25°Cup26.67n.d.up25.66yesGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: L4/A1OP50NGM agarFUDRTJ1052 [age-1(hx546)]25°Cnonen.d.down-2.89noGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/ml1 h; start: young adultsOP50NGM agarGR1352 {daf-16(mgDf47); xrIs87 [daf-16(alpha)::GFP::daf-16B + rol-6(su1006)]}25°Cupyesyoung adultsGuha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlwhole life; start: unknownOP50NGM agarN2 (wild type)25°Cup-regulation of hsp-12.6, sod-3, and daf-16; down-regulation of hsp-4, hsp-16.1, and hsp-16.49daf-16, daf-2, age-1, osr-1, and unc-43Guha S, Cao M, Kane RM, Savino AM, Zou S, Dong Y (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr) 35, 1559-1574.
2 mg/mlfrom eggs - L3OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup13,4yesL3; shifted to 25°C; attractant: OP50upn.d.L4; 25°C exposure for 24h prior measurement; paralysis assaydown-53,5yesL4; 25°C exposure for 24h prior measurement; Aβ expression determined via qRT-PCR; similar but weaker results via western blotGuo, H., Dong, Y. Q., & Ye, B. P. (2016). Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease. Chin J Nat Med, 14(6), 427-433. doi:10.1016/S1875-5364(16)30039-5
2 mg/mlwhole life; start: L3OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup6,6yesL3; shifted to 25°C; attractant: OP50upn.d.L4; 25°C exposure for 24h prior measurement; paralysis assay; very weak effectdown-37,4yesL4; 25°C exposure for 24h prior measurement; Aβ expression determined via qRT-PCR; similar but weaker results via western blotGuo, H., Dong, Y. Q., & Ye, B. P. (2016). Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease. Chin J Nat Med, 14(6), 427-433. doi:10.1016/S1875-5364(16)30039-5
2 mg/mlwhole life; start: egg stageOP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup19,4yesL3; shifted to 25°C; attractant: OP50upn.d.L4; 25°C exposure for 24h prior measurement; paralysis assaydown-69,6yesL4; 25°C exposure for 24h prior measurement; Aβ expression determined via qRT-PCR; similar but weaker results via western blotGuo, H., Dong, Y. Q., & Ye, B. P. (2016). Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease. Chin J Nat Med, 14(6), 427-433. doi:10.1016/S1875-5364(16)30039-5