Treatment | Cranberry extract standardized to 4.0% proanthocyanidins | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | | ChEMBL | | | | | intestinal bacteria colonization | | | | activity / quantity / expression of HSPs | | | | phosphorylation level of PMK-1 | | | | median lifespan | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
2 mg/ml | whole life; start: L1 | OP50 | NGM agar | FUDR | N2 (wild type) | 25°C | | | | | | | | | up | | n.d. | measured via western blot | up | 14.29 | n.d. | | up | 20.74 | yes | | up-regulation of clec-46, clec-71, fmo-2, pqn-5, hsp-16.2, and C23G10.1 | | | hsf-1, p38 MAPK signaling, and insulin/IGF-1 signaling (IIS) | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | up | 11.11 | n.d. | | up | 13.43 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | AU1 [sek-1(ag1)] | 25°C | | | | | | | | | | | | | none | | n.d. | | up | 2.81 | no | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | KU25 [pmk-1(km25)] | 25°C | | | | | | | | | | | | | none | | n.d. | | up | 2.84 | no | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | CB1370 [daf-2(e1370)] | 25°C | | | | | | | | | | | | | none | | n.d. | | up | 2.06 | no | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | TJ1052 [age-1(hx546)] | 25°C | | | | | | | | | | | | | none | | n.d. | | up | 2.48 | no | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | GR1307 [daf-16(mgDf50)] | 25°C | | | | | | | | | | | | | up | 25 | n.d. | | up | 13.54 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | PS3551 [hsf-1(sy441)] | 25°C | | | | | | | | | | | | | none | | n.d. | | up | 4.81 | no | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | VC1668 [fmo-2(ok2147)] | 25°C | | | | | | | | | | | | | | | | | up | 25.91 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | RB1573 [dod-22(ok1918)] | 25°C | | | | | | | | | | | | | | | | | up | 16.32 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Vibrio cholerae (C6706) | NGM agar | FUDR | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | | | | | up | | n.d. | | | | | | | | | | | | | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: egg stage | Vibrio cholerae (JZV133) | NGM agar | FUDR | N2 (wild type) | 20°C | down | | yes | A3; measured via counting CFUs; no change when measuring fluorescence of GFP-expressing bacteria | | | | | | | | | | | | | | | | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Staphylococcus aureus | NGM agar | FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | up | 23.08 | n.d. | | up | 21.69 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Pseudomonas aeruginosa | NGM agar | FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | up | 22.22 | n.d. | | up | 25.55 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Enterococcus faecalis | NGM agar | FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | up | 18.18 | n.d. | | up | 12.16 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: Salmonella typhimurium | NGM agar | FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | up | 12.5 | n.d. | | up | 15.97 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |
2 mg/ml | whole life; start: L1 | OP50 until L4; from A1: E. coli O157:H7 | NGM agar | FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | up | 18.18 | n.d. | | up | 16.63 | yes | | | | | | Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M, Dong Y (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS One 9, e103290. | |