Compound ID 136 (prev - next)

Name: Curcumin (969516) (edit)

28 entries:

Treatment	Curcumin						cognitive function				physical function				physiological function				healthspan biomarkers																				lifespan								Target	Reference
CID (PubChem)	969516	ChEMBL	CHEMBL116438				chemotaxis				locomotion on solid media				oxidative stress resistance				ROS level				activity / quantity / expression of HSPs				quantity of α-synuclein				activity / quantity / expression of SODs				activity / quantity / expression of GSTs				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
10 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C									up		yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C									up	41.83	yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																									hsp-16.2, gst-4, age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1 , and mev-1	Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
100 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C									up		yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
200 µM	whole life; start: L1	OP50	liquid S-medium		N2 (wild type)	20°C									up		yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		TK22 [mev-1(kn1)]	20°C									up	27.24	yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		CB1370 [daf-2(e1370)]	20°C									up	42.99	yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		TJ1052 [age-1(hx546)]	20°C									up	13.93	no	A1; stressor: 250 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		GR1310 [akt-1(mg144)]	20°C									up	3.31	no	A1; stressor: 250 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		GR1318 [pdk-1(mg142)]	20°C									down	-1.48	no	A1; stressor: 250 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		GR1307 [daf-16(mgDf50)]	20°C									up	31.99	yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		AM1 [osr-1(rm1)]	20°C									down	-2.65	no	A1; stressor: 50 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		MT2605 [unc-43(n498n1186)]	20°C									down	-4.55	no	A1; stressor: 250 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		AU1 [sek-1(ag1)]	20°C									up	5.45	no	A1; stressor: 250 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C									down	-5.80	no	A1; stressor: 250 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		VC199 [sir-2.1(ok434)]	20°C									down	-6.87	no	A1; stressor: 250 µM juglone; endpoint: survival	none		no	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		FK171 [mek-1(ks54)]	20°C									up	41.97	yes	A1; stressor: 250 µM juglone; endpoint: survival	down		yes	A1; measured via H2DCF-DA																										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																									none		no	A1; sod-3 expression; measured via fluorescence														Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}	20°C																													up		yes	A1; gst-4 expression; measured via fluorescence										Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
20 µM	whole life; start: L1	OP50	liquid S-medium		CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																	up		yes	A1; measured via fluorescence																						Yu CW, Wei CC, Liao VH (2014) Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379.
100 µM	whole life; start: L4/A1	OP50, heat-inactivated	NGM agar		CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	16°C					up	21.12	yes	young adults; endpoint: ratio of non-paralyzed and paralyzed worms																																		Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
100 µM	whole life; start: L3	OP50, heat-inactivated	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C					up	169.62	yes	young adults; pre-exposed to 25°C; endpoint: ratio of non-paralyzed and paralyzed worms 36 h after temperature shift; similar results 30 h after shift; no significant change 24 h after shift																																		Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
100 µM	whole life; start: L1	OP50, heat-inactivated	NGM agar		CL2122 {dvIs15 [(pPD30.38) unc-54(vector) + (pCL26) mtl-2::GFP]}	16°C	none		no	attractant: benzaldehyde																																						Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
100 µM	whole life; start: L1	OP50, heat-inactivated	NGM agar		CL2355{smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]}	16°C	up	38.29	yes	attractant: benzaldehyde																																						Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR (2017) Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect 7, 207-214.
100 µM	whole life; start: L4/A1	OP50	NGM agar	FUDR	N2 (wild type)	20°C																																	up	22.54	n.d.		up	15.07	n.d.			Li J, Cui X, Wang Z, Li Y (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp Gerontol 67, 62-71.
5 µM	whole life; start: L1	OP50	liquid S-medium		NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]}	20°C																					down	-13	yes	L4																		Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125.