Treatment | Xyloketal, derivate 15 | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | | | | | | | pharyngeal pumping | | | | locomotion in liquid media | | | | locomotion on solid media | | | | heat stress resistance | | | | activity / quantity / expression of HSPs | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
100 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 20°C | | | | | | | | | | | | | up | 15,4 | yes | A1; stressor: 37°C; endpoint: survival | | | | | | | | | | | | HSF-1 | Zhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72. | |
300 µM | whole life; start: L1 | OP50 | NGM agar | | N2 (wild type) | 20°C | up | 16 | yes | A1-A13 | up | 22 | yes | L4-A18 | | | | | up | 24 | yes | A1; stressor: 37°C; endpoint: survival | up | 28 | yes | A4; quantity of HSP-70; 37°C for 1h beforehand | up | 11 | yes | | | | | HSF-1 | Zhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72. | |
300 µM | whole life; start: L1 | OP50 | NGM agar | | PS3551 [hsf-1(sy441)] | 20°C | | | | | | | | | | | | | none | | no | A1; stressor: 37°C; endpoint: survival | | | | | none | | no | | | | | | Zhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72. | |
300 µM | whole life; start: L1 | OP50 | NGM agar | | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 15°C | | | | | | | | | up | | yes | L3; paralysis assay; shifted to 26°C | | | | | | | | | | | | | | | | | Zhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72. | |