Compound ID 14   (prev - next)

Name: Xyloketal, derivate 15 (edit)

7 entries:
TreatmentXyloketal, derivate 15physical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)pharyngeal pumpinglocomotion in liquid medialocomotion on solid mediaheat stress resistanceactivity / quantity / expression of HSPsmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup15,4yesA1; stressor: 37°C; endpoint: survivalHSF-1Zhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72.
300 µMwhole life; start: L1OP50NGM agarN2 (wild type)20°Cup16yesA1-A13up22yesL4-A18up24yesA1; stressor: 37°C; endpoint: survivalup28yesA4; quantity of HSP-70; 37°C for 1h beforehandup11yesHSF-1Zhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72.
300 µMwhole life; start: L1OP50NGM agarPS3551 [hsf-1(sy441)]20°CnonenoA1; stressor: 37°C; endpoint: survivalnonenoZhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72.
300 µMwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}15°CupyesL3; paralysis assay; shifted to 26°CZhou, J. B., Zheng, Y. L., Zeng, Y. X., Wang, J. W., Pei, Z., & Pang, J. Y. (2018). Marine derived xyloketal derivatives exhibit anti-stress and anti-ageing effects through HSF pathway in Caenorhabditis elegans. European journal of medicinal chemistry, 148, 63-72.