Treatment | 3,3-Diethyl-2-pyrrolidinon (DEABL) | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 9793807 | ChEMBL | mean lifespan | maximum lifespan | ||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
2 mg/ml | whole life; start: parental generation | OP50 | NGM agar | N2 (wild type) | 20°C | up | 31.00 | yes | up | 49.00 | yes | Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262. |