Treatment | DETA NONOate (NO donor) | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 135402056 | ChEMBL | mean lifespan | |||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
1 mM | 3 times at L4, A2 and A4 | OP50 | NGM agar | N2 (wild type) | 20°C | up | 8.90 | yes | Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830. |