| Treatment | Diallyldisulfide | physiological function | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 16590 | ChEMBL | heat stress resistance | oxidative stress resistance | activity / quantity / expression of GSTs | |||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 10 µM | whole life; start: A1 | OP50, UV-inactivated | liquid S-medium | amphotericin B | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | up | 240.00 | yes | A2; expression of gst-4; measured via fluorescence | Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611. | |||||||||||||
| 10 µM | whole life; start: A1 | OP50, UV-inactivated | liquid S-medium | FUDR, amphotericin B | N2 (wild type) | 20°C | up | yes | A3; stressor: 35 °C for 7 h; endpoint: survival | up | 161.88 | yes | A3; stressor: 250 µM juglone for 2 h; endpoint: survival | Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6, 21611. | ||||||||||