Treatment | Dibromoacetic acid | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 12433 | ChEMBL | CHEMBL449362 | pharyngeal pumping | body length / growth rate | number of offspring | vertex (progeny per day) | heat stress resistance | MDA level | median lifespan | mean lifespan | maximum lifespan | minimum lifespan | |||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
50 µM | whole life; start: parental generation | OP50 | NGM agar | N2 (wild type) | 20°C | up | no | A6 | up | yes | A6 | none | no | none | no | none | no | A1; stressor: 35°C; endpoint: survival | down | no | A1 | up | 6.57 | n.d. | up | 7.65 | yes | up | 6.59 | n.d. | up | 12.57 | n.d. | down-regulation of cep-1, rad-51, hsp-16.1, hsp-70, gst-4, gst-38, gstk-1, cyp-35A2, and sod-1 | Baberschke N, Steinberg CE, Saul N (2015) Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans. Chemosphere 124, 122-128. | no | ||||||||||||||||
100 µM | whole life; start: parental generation | OP50 | NGM agar | N2 (wild type) | 20°C | up | no | A6 | up | yes | A6 | up | 15.82 | n.d. | up | 14.57 | yes | up | 0.76 | n.d. | up | 38.21 | n.d. | Baberschke N, Steinberg CE, Saul N (2015) Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans. Chemosphere 124, 122-128. | no | |||||||||||||||||||||||||||
0.1 mM | whole life; start: parental generation | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | none | no | none | no | A1; stressor: 35°C; endpoint: survival | down-regulation of cep-1, egl-1, rad-51, hsp-16.1, hsp-70, gst-38, gstk-1, cyp-35A2, sod-5, and sod-1 | Baberschke N, Steinberg CE, Saul N (2015) Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans. Chemosphere 124, 122-128. | no | |||||||||||||||||||||||||||||||||||||
0.5 µM | whole life; start: parental generation | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | none | no | none | no | A1; stressor: 35°C; endpoint: survival | Baberschke N, Steinberg CE, Saul N (2015) Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans. Chemosphere 124, 122-128. | no | ||||||||||||||||||||||||||||||||||||||
2 µM | whole life; start: parental generation | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | none | no | none | no | A1; stressor: 35°C; endpoint: survival | Baberschke N, Steinberg CE, Saul N (2015) Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans. Chemosphere 124, 122-128. | no | ||||||||||||||||||||||||||||||||||||||
10 µM | whole life; start: parental generation | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | none | no | none | no | A1; stressor: 35°C; endpoint: survival | Baberschke N, Steinberg CE, Saul N (2015) Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans. Chemosphere 124, 122-128. | no |