Compound ID 155   (prev - next)

Name: Dichloroacetate (DCA) (25975) (edit)

5 entries:
TreatmentDichloroacetate (DCA)physical functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)25975ChEMBLpharyngeal pumpinglocomotion on solid mediabody length / growth ratequantity of carbonylated proteinsROS levelATP levelGSH leveltriglyceride / fat / lipid contentmedian lifespanmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
50 µg/mlwhole life; start: L4OP50, heat-inactivatedNGM agarFUDRN2 (wild type)20°CnonenoA3upyesA8, A16, A21; unchanged at A4down-1.77noA3nonenoA3downyesA3; measured with DCF-DAup50.00yesA3nonenoA3nonenoup11.77n.d.only one trialup19.22yesonly one trialup16.03yesonly one trialSchaffer S, Gruber J, Ng LF, Fong S, Wong YT, Tang SY, Halliwell B (2011) The effect of dichloroacetate on health- and lifespan in C. elegans. Biogerontology 12, 195-209.
50 µg/mlwhole life; start: L4OP50NGM agarFUDRN2 (wild type)20°Cup5.79n.d.up6.73yes3 from 4 trials are significantup6.79variable2 from 4 trials are significantSchaffer S, Gruber J, Ng LF, Fong S, Wong YT, Tang SY, Halliwell B (2011) The effect of dichloroacetate on health- and lifespan in C. elegans. Biogerontology 12, 195-209.