Treatment | Dichloroacetate (DCA) | physical function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 25975 | ChEMBL | pharyngeal pumping | locomotion on solid media | body length / growth rate | quantity of carbonylated proteins | ROS level | ATP level | GSH level | triglyceride / fat / lipid content | median lifespan | mean lifespan | maximum lifespan | |||||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
50 µg/ml | whole life; start: L4 | OP50, heat-inactivated | NGM agar | FUDR | N2 (wild type) | 20°C | none | no | A3 | up | yes | A8, A16, A21; unchanged at A4 | down | -1.77 | no | A3 | none | no | A3 | down | yes | A3; measured with DCF-DA | up | 50.00 | yes | A3 | none | no | A3 | none | no | up | 11.77 | n.d. | only one trial | up | 19.22 | yes | only one trial | up | 16.03 | yes | only one trial | Schaffer S, Gruber J, Ng LF, Fong S, Wong YT, Tang SY, Halliwell B (2011) The effect of dichloroacetate on health- and lifespan in C. elegans. Biogerontology 12, 195-209. | ||||||||||||
50 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 5.79 | n.d. | up | 6.73 | yes | 3 from 4 trials are significant | up | 6.79 | variable | 2 from 4 trials are significant | Schaffer S, Gruber J, Ng LF, Fong S, Wong YT, Tang SY, Halliwell B (2011) The effect of dichloroacetate on health- and lifespan in C. elegans. Biogerontology 12, 195-209. |