Compound ID 156 (prev - next)

Name: Diethyl maleate (5271566) (edit)

19 entries:

Treatment	Diethyl maleate						physiological function				healthspan biomarkers												lifespan								Transcriptome	Target	Reference
CID (PubChem)	5271566	ChEMBL					oxidative stress resistance				thiol level				GSH level				translocation of DAF-16 to nucleus				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
1 µM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	N2 (wild type)	20°C																	up	0.83	no		variable	0.84	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
10 µM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	N2 (wild type)	20°C																	up	1.75	no		variable	1.67	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
100 µM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	N2 (wild type)	20°C																	up	4.64	yes		up	4.32	n.d.		A3-A10: up-regulation of sod-3, gcs-1, ctl-1, ctl-2, egl-1, gst-4, gei-7, and gst-10	DAF-16 and SKN-1	Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
1 mM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	N2 (wild type)	20°C																	down	-6.65	yes		down	-6.22	n.d.		A3: down-regulation of gcs-1 and ctl-2; up-regulation of ctl-2 and egl-1 (ctl-2 is regulated in different ways according to exposure time)		Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
1 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	ampicillin	N2 (wild type)	20°C	down	-3.34	no	A5; stressor: 10 mM paraquat; endpoint: survival													up	8.34	yes		up	13.33	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
10 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	ampicillin	N2 (wild type)	20°C	up	6.92	yes	A5; stressor: 10 mM paraquat; endpoint: survival													up	6.53	yes		up	16.67	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
100 µM	whole life; start: L4	OP50, heat-inactivated	NGM agar	ampicillin	N2 (wild type)	20°C	variable	variable	no	A5; stressor: 10 mM paraquat; endpoint: survival					down		yes	A5; no significant change in L4/A1					up	0.98	no		up	6.67	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
1 mM	whole life; start: L4	OP50, heat-inactivated	NGM agar	ampicillin	N2 (wild type)	20°C	down	-19.44	yes	A5; stressor: 10 mM paraquat; endpoint: survival					down		yes	A5; no significant change in L4/A1					down	-18.53	yes		down	-15.00	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
100 µM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]	20°C																	up	1.34	no		variable	1.39	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
1 mM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]	20°C																	down	-6.21	yes		down	-4.54	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
100 µM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	CF1038 [daf-16(mu86)]	20°C																	variable	variable	variable	only one trial showed significantly decreased mean lifespan; 3 further trials showed no difference	variable	variable	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
1 mM	whole life; start: L4	OP50; from A12: OP50-1	NGM agar	streptomycin (from A12)	CF1038 [daf-16(mu86)]	20°C																	down	-5.89	yes		down	-4.62	n.d.				Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
0.1 mM	whole life; start: L1	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C													up		no	L3											Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
1 mM	whole life; start: L1	OP50	NGM agar		TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C													up		yes	L3											Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
100 µM	2-3 h; start: L4/A1	OP50	NGM agar		N2 (wild type)	20°C					down	-25.00	no	L4/A1; measured in vivo with monobromobimane (MBBr) or in vitro with dithionitrobenzoate (DTNB)																			Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.
1 mM	2-3 h; start: L4/A1	OP50	NGM agar		N2 (wild type)	20°C					down	-25.00	yes	L4/A1; measured in vivo with monobromobimane (MBBr) or in vitro with dithionitrobenzoate (DTNB)																			Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO (2017) Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol 11, 502-515.