Treatment | Eleutherococcus senticosus root extract | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | ChEMBL | heat stress resistance | oxidative stress resistance | UV stress resistance | activity / quantity / expression of HSPs | translocation of DAF-16 to nucleus | mean lifespan | maximum lifespan | minimum lifespan | |||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 5.34 | yes | up | 2.40 | n.d. | up | 6.02 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 22.18 | yes | A4; Stressor: 35°C for 3 hours; Counting dead & alive 3 days after stress; when using 26°C as stressor, percentual change to control = 88.29 % | up | 27.23 | yes | A4; Stressor: 10 mM Paraquat for 4 days | up | 60.84 | yes | A4; Stressor: UV with 1000 J/m2; Counting dead & alive 3 days after stress | up | 15.79 | yes | up | 12.02 | n.d. | up | 22.89 | n.d. | DAF-16; HSP-16.2 | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | |||||||||||||||
500 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 7.46 | yes | up | 7.21 | n.d. | up | 8.43 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
1000 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | -6.21 | no | down | -4.81 | n.d. | none | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||
2500 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | -22.94 | yes | down | -13.46 | n.d. | down | -15.66 | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||
100 µg/ml | whole life; start: A5 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 7.90 | yes | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: A5 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | up | 11.70 | yes | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
500 µg/ml | whole life; start: A5 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | none | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||||
1000 µg/ml | whole life; start: A5 | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | down | -6.4 | yes | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TK22 [mev-1(kn1)] | 20°C | up | 9.19 | yes | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | n.d. | only weak induction | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | |||||||||||||||||||||||||||||||||||
500 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | |||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Quantification via Westernblot | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. | ||||||||||||||||||||||||||||||||||
500 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUDR | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | up | n.d. | Quantification via Westernblot | Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10, 27-42. |