Compound ID 167 (prev - next)

Name: Ellagic acid (5281855) (edit)

12 entries:

Treatment	Ellagic acid						physical function												reproductive function												physiological function								healthspan biomarkers								lifespan				Reference	blinded
CID (PubChem)	5281855	ChEMBL					pharyngeal pumping				locomotion on solid media				body length / growth rate				number of offspring				quantity of early reproduction				onset of egg laying				heat stress resistance				oxidative stress resistance				triglyceride / fat / lipid content				antioxidative capacity				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
25 µM	whole life; start: parental generation	OP50	NGM agar		N2 (wild type)	20°C																									none		no	A6; Stressor: 35°C for 8 h; endpoint: survival	none		no	A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival									up		no		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
50 µM	whole life; start: parental generation	OP50	NGM agar		N2 (wild type)	20°C	down		no	A6 & A9; unchanged at A3					none		no	A6	none		no		down		yes		delayed		yes		none		no	A6; Stressor: 35°C for 8 h; endpoint: survival	down		yes	A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival	down		no		up		yes	A1; significant for water-soluble metabolites; unchanged capacity for lipid-soluble metabolites	up		yes		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
100 µM	whole life; start: parental generation	OP50	NGM agar		N2 (wild type)	20°C																									none		no	A6; Stressor: 35°C for 8 h; endpoint: survival	down		yes	A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival									none		no		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
200 µM	whole life; start: parental generation	OP50	NGM agar		N2 (wild type)	20°C																									up		no	A6; Stressor: 35°C for 8 h; endpoint: survival	down		yes	A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival									none		no		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
300 µM	whole life; start: parental generation	OP50	NGM agar		N2 (wild type)	20°C																									down		yes	A6; Stressor: 35°C for 8 h; endpoint: survival	down		yes	A6; Stressor: 0.8 mM H2O2 for 8 h; endpoint: survival									down		yes		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
50 µM	whole life; start: parental generation	OP50	NGM agar		TK22 [mev-1(kn1)]	20°C																																									up		yes		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
50 µM	whole life; start: parental generation	OP50	NGM agar		DA465 [eat-2(ad465)]	20°C																																									none		no		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
50 µM	whole life; start: parental generation	OP50 until A6; from A6: OP50, heat-inactivated	NGM agar		N2 (wild type)	20°C																																									none		no		Saul N, Pietsch K, Stürzenbaum SR, Menzel R, Steinberg CE (2011) Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity. J Nat Prod 74, 1713-1720.	no
50 µM	whole life; start: egg stage	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A7; unchanged pumping at A14	down		yes	A1; no significant differences at A5 & A8																																	down	-4,3	no		Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.