Compound ID 174   (prev - next)

Name: Fluoxetine (3386) (edit)

13 entries:
TreatmentFluoxetinecognitive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)3386ChEMBLmechanical sensory / touch responseheat stress resistancequantity of β-Amyloidtranslocation of DAF-16 to nucleusmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
1 µMwhole life; start: egg stageOP50NGM agarCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°Cnoneparalysis assay with daily measurements of Alzheimer disease modelKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
10 µMwhole life; start: egg stageOP50NGM agarCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°Cupyesparalysis assay with daily measurements of Alzheimer disease modelnoneKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
100 µMwhole life; start: egg stageOP50NGM agarCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°Cnoneparalysis assay with daily measurements of Alzheimer disease modelupyesKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µMwhole life; start: egg stageOP50NGM agarCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°Cupyesparalysis assay with daily measurements of Alzheimer disease modeldownnoA1; no change of total amyloid beta levelnonedaf-16 & tph-1Keowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µMwhole life; start: egg stageHT115 (DE3) with RNAi-vector against daf-16NGM agarCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°Cnonenoparalysis assay with daily measurements of Alzheimer disease modelKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µMwhole life; start: egg stageHT115 (DE3) with RNAi-vector against hsf-1NGM agarCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°Cupyesparalysis assay with daily measurements of Alzheimer disease modelKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µMwhole life; start: egg stageHT115 (DE3) with RNAi-vector against tph-1NGM agarCL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}20°Cnonenoparalysis assay with daily measurements of Alzheimer disease modelKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µMwhole life; start: egg stageOP50NGM agarTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µMwhole life; start: egg stageOP50NGM agarN2 (wild type)20°Cup38.00yesA1; Stressor: 35°C for 7 hoursKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.
1000 µMwhole life; start: egg stageOP50NGM agarunknown strain [daf-16 deletion mutant]20°CnonenoA1; Stressor: 35°C for 7 hoursKeowkase R, Aboukhatwa M, Luo Y (2010) Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365.