| Treatment | Geldanamycin | physical function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 5288382 | ChEMBL | pharyngeal total span | locomotion on solid media | mean lifespan | |||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 20 µM | whole life; start: L4 | OP50, ethanol- and UV-inactivated | NGM agar | FUDR | N2 (wild type) | 20°C | down | yes | A5; non-significantly decreased at A1 and A10; unchanged at A15 | down | yes | A5, A10, and A15; unchanged at A1; endpoint: number of body bends | up | 1.98 | no | Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266. | ||||||||
| 20 µM | whole life; start: L4 | OP50, ethanol- and UV-inactivated | NGM agar | FUDR | DA465[eat-2(ad465)] | 20°C | up | 6.89 | no | Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266. | ||||||||||||||