Compound ID 178   (prev - next)

Name: Genistein (5280961) (edit)

9 entries:
TreatmentGenisteinphysical functionreproductive functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)5280961ChEMBLpharyngeal pumpinglocomotion on solid mediabody length / growth ratenumber of offspringvertex (progeny per day)heat stress resistanceoxidative stress resistanceactivity / quantity / expression of HSPsactivity / quantity / expression of SODsactivity / quantity / expression of CTLsmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
50 µMwhole life; start: unknownOP50NGM agarN2 (wild type)20°CdownnoA4up11.50yesA4; endpoint: travel rangenonenoA4downnononeupnoA4; stressor: 36°C; endpoint: survivalupnoA7; stressor: 85 mM paraquat; endpoint: survivalupyesA5; activity of SODupyesA5upyesSOD-3, HSP-16.2Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83.
100 µMwhole life; start: unknownOP50NGM agarN2 (wild type)20°CdownnoA4up13.70yesA4; endpoint: travel rangenonenoA4downnononeup68.40yesA4; stressor: 36°C; endpoint: survivalupyesA7; stressor: 85 mM paraquat; endpoint: survivalup7.07yesA5; activity of SODup17.80yesA5up27.90yesLee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83.
50 µMwhole life; start: unknownOP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA3; measurement of sod-3 expression via fluorescenceLee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83.
100 µMwhole life; start: unknownOP50NGM agarCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°Cup25.10yesA3; measurement of sod-3 expression via fluorescenceLee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83.
50 µMwhole life; start: unknownOP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°CupyesA3; pre-exposed to 36°C for 2 h; measured via fluorescenceLee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83.
100 µMwhole life; start: unknownOP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°Cup11.10yesA3; pre-exposed to 36°C for 2 h; measured via fluorescenceLee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83.