Treatment | Genistein | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||||||||||
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CID (PubChem) | 5280961 | ChEMBL | pharyngeal pumping | locomotion on solid media | body length / growth rate | number of offspring | vertex (progeny per day) | heat stress resistance | oxidative stress resistance | activity / quantity / expression of HSPs | activity / quantity / expression of SODs | activity / quantity / expression of CTLs | mean lifespan | |||||||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
50 µM | whole life; start: unknown | OP50 | NGM agar | N2 (wild type) | 20°C | down | no | A4 | up | 11.50 | yes | A4; endpoint: travel range | none | no | A4 | down | no | none | up | no | A4; stressor: 36°C; endpoint: survival | up | no | A7; stressor: 85 mM paraquat; endpoint: survival | up | yes | A5; activity of SOD | up | yes | A5 | up | yes | SOD-3, HSP-16.2 | Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83. | ||||||||||||||||||||||
100 µM | whole life; start: unknown | OP50 | NGM agar | N2 (wild type) | 20°C | down | no | A4 | up | 13.70 | yes | A4; endpoint: travel range | none | no | A4 | down | no | none | up | 68.40 | yes | A4; stressor: 36°C; endpoint: survival | up | yes | A7; stressor: 85 mM paraquat; endpoint: survival | up | 7.07 | yes | A5; activity of SOD | up | 17.80 | yes | A5 | up | 27.90 | yes | Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83. | |||||||||||||||||||
50 µM | whole life; start: unknown | OP50 | NGM agar | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | up | yes | A3; measurement of sod-3 expression via fluorescence | Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83. | |||||||||||||||||||||||||||||||||||||||||||||||
100 µM | whole life; start: unknown | OP50 | NGM agar | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | up | 25.10 | yes | A3; measurement of sod-3 expression via fluorescence | Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83. | ||||||||||||||||||||||||||||||||||||||||||||||
50 µM | whole life; start: unknown | OP50 | NGM agar | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | up | yes | A3; pre-exposed to 36°C for 2 h; measured via fluorescence | Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83. | |||||||||||||||||||||||||||||||||||||||||||||||
100 µM | whole life; start: unknown | OP50 | NGM agar | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | up | 11.10 | yes | A3; pre-exposed to 36°C for 2 h; measured via fluorescence | Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK (2015) Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans. Biomol Ther (Seoul) 23, 77-83. |