Compound ID 179   (prev - next)

Name: Ginkgo biloba leaf extract EGb 761 (64927) (edit)

15 entries:
TreatmentGinkgo biloba leaf extract EGb 761cognitive functionphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)64927ChEMBLchemotaxispharyngeal pumpinglocomotion on solid medialocomotion on solid mediaheat stress resistanceoxidative stress resistanceROS levelactivity / quantity / expression of HSPsactivity / quantity / expression of HSPsmuscle integritymedian lifespanmean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
100 µg/mlwhole life; start: A1OP50NGM agarN2 (wild type)22 °Cup25.00yesA1; Stressor: 35°C; 7.69% increase in maximum survivalup33.00yesA1; Stressor: 472 µM Juglone; 17% increase in maximum survival; increased survival also in wild type worms after 40 µM Juglone exposureup8.33yessignificance was determined for mean lifespan (log rank test)up11.11Wu Z, Smith JV, Paramasivam V, Butko P, Khan I, Cypser JR, Luo Y (2002) Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell Mol Biol (Noisy-le-grand) 48, 725-731.
100 µg/mlwhole life; start: A1OP50NGM agarTK22 [mev-1(kn1)]22 °Cup11.00yesA1; Stressor: 35°C; 15.38% increase in maximum survivalup33.00yesA1; Stressor: 472 µM Juglone; 20% increase in maximum survivalWu Z, Smith JV, Paramasivam V, Butko P, Khan I, Cypser JR, Luo Y (2002) Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell Mol Biol (Noisy-le-grand) 48, 725-731.
100 µg/mlwhole life; start: L1OP50NGM agarCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°Cup224.00n.d.A1; Stressor: 35°C for 15 hup21.74n.d.A1; Stressor: 160 µM Juglonedown-24.00yesA1; H2O2-related ROS-leveldown-33.33yesA1; measured by fluorescence intensity after heat shock (35°C for 2 h)down-86.11yesA1; measured by fluorescence intensity after oxidative stress (40 µM juglone for 24 h); Percentual change = -66.67% when EGb 761 & juglone treatment start simultaneously; Percentual change = -50.00% when EGb 761 treatment start after juglone treatmentStrayer A, Wu Z, Christen Y, Link CD, Luo Y (2003) Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. FASEB J 17, 2305-2307.
100 µg/mlwhole life; start: L1OP50NGM agarPD4251 {dpy-20(e1282); ccIs4251 [(pSAK2) myo-3p::GFP::LacZ::NLS + (pSAK4) myo-3p::mitochondrial GFP + dpy-20(+)]}20°Cup8.37yesage-associated muscle cellular deterioration measured by fluorescence; significant changes only in A10, not in A4, A7, and A15; Electron microscopy didn't show remarkable changes in body wall muscle cells in A11up13.33n.d.up9.00yesCao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.
100 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°CupyesA11; unchanged in A8 and A14; slightly decreased (not significant) in A5upyesA3-A15; Fraction of worms moving sinusoidal after prodding or spontaniously; significant changes in A7, A9, and A11upnoSlightly increased (not significant) in A5, A11, A14; unchanged in A8; measured by counting body bendsCao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.
10 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cupn.d.A3-A15; Fraction of worms moving sinusoidal after prodding or spontaniouslyCao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.
500 µg/mlwhole life; start: L1OP50NGM agarN2 (wild type)20°Cupn.d.A3-A15; Fraction of worms moving sinusoidal after prodding or spontaniouslyCao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.
1 mg/mLwhole life; start: egg stageOP50NGM agarGentamycinCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}20°CupyesL3; temperature shift to 23°C prior analysing beta-amyloid induced paralysisdownyesA1; temperature shift to 23°C 30h prior measurementSangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
1 mg/mLwhole life; start: egg stageOP50NGM agarGentamycinN2 (wild type)20°CupyesL4; stressor: 300 µM juglone; endpoint: survivalSangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
100 µg/mlwhole life; start: egg stageOP50NGM agarN2 (wild type)20°Cup29,4yesup31,9yesKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
100 µg/mlwhole life; start: L1OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}16°Cup5,2yesL4; temperature upshift to 25°C at L3; paralysis assayKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.
100 µg/mlwhole life; start: L1OP50NGM agarCL2355 {smg-1(cc546); dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP]}16°CupyesL4/A1; temperature upshift to 25°C at L3; attractant: benzaldehydeKeowkase, R., Shoomarom, N., Bunargin, W., Sitthithaworn, W., & Weerapreeyakul, N. (2018). Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomedicine & Pharmacotherapy, 107, 656-664.