Compound ID 18 (prev - next)

Name: 18α-Glycyrrhetinic acid (73398) (edit)

26 entries:

Treatment	18α-Glycyrrhetinic acid						physical function												reproductive function												physiological function				healthspan biomarkers																								lifespan				Transcriptome	Proteome	Reference
CID (PubChem)	73398	chEMBL					pharyngeal pumping				locomotion on solid media				duration of defecation cycles				number of offspring				speed of larval development				quantity of dauer formation				oxidative stress resistance				quantity of carbonylated proteins				ROS level				quantity of β-Amyloid				activity / quantity / expression of CTLs				proteasomal activity				translocation of SKN-1 to nucleus				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
20 µg/ml	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C	down	-0,6	no	A1					up	3,8	no	A1	up	4,3	no		down	-3,1	yes						none		no	A5; stressor: 2 mM paraquat; from A5: UV-killed OP50; endpoint: survival; in addition: stress-test with 80 mM juglone at A1 with similar result																									up	17,3	yes		A3; upregulation of gst-4, pbs-1, pbs-2, and pbs-5		Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		N2 (wild type)	27°C																					up	300	no																																				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
10 µg/ml	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C																																																					down	-5,9	no				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
100 µg/ml	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C																																																					up	11,8	yes				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: egg stage	OP50	NGM agar		N2 (wild type)	20°C																													down	-44	yes	72h-treatment; 48h and 96h treatment: -18% and -40%, resp.	down		no	A1; superoxide anion production					up		yes	A1	up		yes	A1; significant for 20S and 30S/26S complex and for CT-L & T-L, but not for PGPH (PGPH = peptidylglutamyl peptide hydrolyzing, T-L = trypsin-like, CT-L = chymotrypsin-like proteolytic activities )										A1; up-regulation of PAS-1-7, PBS-5, RPT-6, p-P38	Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: egg stage	OP50	NGM agar		EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C																																													down		no	A1; CT-L proteasome activity											Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]]	20°C																																																					none		no				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		EU1 [skn-1(zu67)/nT1 [unc-?(n754) let-?]], heterozygous	20°C																																																					up	50	yes				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]	20°C																																																					down	-7,7	no				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		EU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]], heterozygous	20°C																																																					up	45,5	yes				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		EU40 [skn-1(zu129)/nT1[unc-?(n754) let-?]]	20°C																																																					up	4,3	no				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		EU40 [skn-1(zu129)/nT1[unc-?(n754) let-?]], heterozygous	20°C																																																					up	50	yes				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	20°C					up	26,8	yes	A1; paralysis assay																																													up	18,2	yes			A6; upregulation of PAS-1-7, PBS-5, RPT-6, RPN-12	Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		LD001 {ldIs007 [skn-1p::SKN-1::gfp]; pRF4 [rol-6(su1006gf)]}	20°C																																																	up	8,3	yes	A2							Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		unknown strain; genotype: [{[Pvha-6::UIM2-ZsProSensor]}	20°C																																													up		n.d.												Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		DR26 [daf-16(m26)]	20°C																																																					down	-9	yes				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C					up	3,1	yes	A3; temperature upshift to 25°C for 24h prior measurement; paralysis assay																													down		yes	A2																			Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	HT115 (DE3) with RNAi-vector against pbs-5	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C					down	-3	no	A3; temperature upshift to 25°C for 24h prior measurement; paralysis assay																													down		yes	A2																			Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	HT115 (DE3)	NGM agar		CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C					up	6,1	yes	A3; temperature upshift to 25°C for 24h prior measurement; paralysis assay																													down		yes	A2																			Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	OP50	NGM agar		CL2331 {dvIs37 [myo-3p::GFP::A-Beta (3-42) + rol-6(su1006)]}	20°C																																					down		yes	A2																			Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	HT115 (DE3) with RNAi-vector against pbs-5	NGM agar		N2 (wild type)	20°C																																																					none		no				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	HT115 (DE3) with RNAi-vector against skn-1	NGM agar		N2 (wild type)	20°C																																																					up	2,5	no				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.
20 µg/ml	whole life; start: L4	HT115 (DE3)	NGM agar		N2 (wild type)	20°C																																																					up	6,3	yes				Papaevgeniou, N., Sakellari, M., Jha, S., Tavernarakis, N., Holmberg, C. I., Gonos, E. S., & Chondrogianni, N. (2016). 18α-Glycyrrhetinic acid proteasome activator decelerates aging and Alzheimer's disease progression in caenorhabditis elegans and neuronal cultures. Antioxidants & redox signaling, 25(16), 855-869.