| Treatment | Glycerol | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 753 | ChEMBL | CHEMBL692 | heat stress resistance | autofluorescence (age pigment / lipofuscin) | mean lifespan | ||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 400 mM | whole life; start: A1 | N/A | NGM agar | N2 (wild type) | 20°C | none | n.d. | A1; 35°C; exposure start at L4 | down | n.d. | A9; green fluorescence | down | no | Deocaris CC, Takano S, Priyandoko D, Kaul Z, Yaguchi T, Kraft DC, Yamasaki K, Kaul SC, Wadhwa R (2008) Glycerol stimulates innate chaperoning, proteasomal and stress-resistance functions: implications for geronto-manipulation. Biogerontology 9, 269-282. | no | |||||||||
| 600 mM | whole life; start: A1 | N/A | NGM agar | N2 (wild type) | 20°C | up | n.d. | A1; 35°C; exposure start at L4 | down | n.d. | A9; green fluorescence | none | no | Deocaris CC, Takano S, Priyandoko D, Kaul Z, Yaguchi T, Kraft DC, Yamasaki K, Kaul SC, Wadhwa R (2008) Glycerol stimulates innate chaperoning, proteasomal and stress-resistance functions: implications for geronto-manipulation. Biogerontology 9, 269-282. | no | |||||||||