Treatment | Gracilaria lemaneiformis polysaccharide | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||
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CID (PubChem) | ChEMBL | pharyngeal pumping | quantity of early reproduction | quantity of late reproduction | oxidative stress resistance | heat stress resistance | translocation of DAF-16 to nucleus | quantity of polyQ aggregates | mean lifespan | maximum lifespan | ||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
250 µg/ml | whole life; start: L4/A1 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | A5, A8, A10 | none | no | none | no | none | no | A6; stressor: 250 µM juglone; endpoint: survival | none | no | A6; stressor: 35°C; endpoint: survival | up | 7.45 | no | up | no | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | |||||||||||||||||||||||
500 µg/ml | whole life; start: L4/A1 | OP50 | NGM agar | N2 (wild type) | 20°C | variable | no | A5, A8, A10 | none | no | none | no | none | no | A6; stressor: 250 µM juglone; endpoint: survival | none | no | A6; stressor: 35°C; endpoint: survival | up | 16.47 | yes | up | no | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | |||||||||||||||||||||||
1000 µg/ml | whole life; start: L4/A1 | OP50 | NGM agar | N2 (wild type) | 20°C | variable | no | A5, A8, A10 | up | yes | none | no | none | no | A6; stressor: 250 µM juglone; endpoint: survival | none | no | A6; stressor: 35°C; endpoint: survival | up | 9.96 | no | up | no | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | |||||||||||||||||||||||
250 µg/ml | whole life; start: L1 | OP50 | NGM agar | AM141 {rmIs133 [unc-54p::Q40::YFP]} | 20°C | down | -24.82 | yes | A1 | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | |||||||||||||||||||||||||||||||||||||
500 µg/ml | whole life; start: L1 | OP50 | NGM agar | AM141 {rmIs133 [unc-54p::Q40::YFP]} | 20°C | down | -32.08 | yes | A1 | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | |||||||||||||||||||||||||||||||||||||
1000 µg/ml | whole life; start: L1 | OP50 | NGM agar | AM141 {rmIs133 [unc-54p::Q40::YFP]} | 20°C | down | -30.93 | yes | A1 | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | |||||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L2/L3 | OP50 | NGM agar | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | yes | A1 | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | ||||||||||||||||||||||||||||||||||||||
500 µg/ml | whole life; start: L2/L3 | OP50 | NGM agar | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | yes | A1 | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no | ||||||||||||||||||||||||||||||||||||||
1000 µg/ml | whole life; start: L2/L3 | OP50 | NGM agar | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | yes | A1 | Wang X, Zhang Z, Zhou H, Sun X, Chen X, Xu N (2019) The anti-aging effects of Gracilaria lemaneiformis polysaccharide in Caenorhabditis elegans. Int J Biol Macromol, 140, 600-604. | no |