| Treatment | Hibiscus calyces extract (Hibiscus sabdariffa) | physiological function | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | heat stress resistance | proteasomal activity | |||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 0.1 % (w/w) | whole life; start: A1 | OP50 | liquid NGM | 10 mM glucose, Carbenicillin | N2 (wild type) | 20°C | up | yes | A3; Stressor: 37°C; endpoint: mean lifespan | up | yes | A3 | Fitzenberger E, Deusing DJ, Wittkop A, Kler A, Kriesl E, Bonnländer B, Wenzel U (2014) Effects of plant extracts on the reversal of glucose-induced impairment of stress-resistance in Caenorhabditis elegans. Plant Foods Hum Nutr 69, 78-84. | |||||||