Treatment | Hidrox® | cognitive function | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | ChEMBL | neuronal survival / integrity | locomotion in liquid media | body wave number | heat stress resistance | quantity of α-synuclein | autofluorescence (age pigment / lipofuscin) | mean lifespan | maximum lifespan | median lifespan | ||||||||||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
100 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 22°C | up | yes | A3; stressor: 37°C for 3h; endpoint: mean survival | up | up | Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. | no | |||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 22°C | up | 48 | yes | A12; endpoint: activity index; similar changes at A3 and A7 and for the wave initiation rate at all ages | down | -27 | yes | A3, A7 & A12 | up | 40 | yes | A3; stressor: 37°C for 3h; endpoint: mean survival | down | -3 | yes | A12; no significant changes at A3 & A7; red fluorescence | up | 12 | yes | up | 7 | no | up | 16 | yes | Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. | no | |||||||||||||||
500 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | N2 (wild type) | 22°C | up | yes | A3; stressor: 37°C for 3h; endpoint: mean survival | up | Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. | no | ||||||||||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | OW13 {grk-1(ok1239); pkIs2386 [unc-54p:: α-synuclein::YFP + unc-119(+)]} | 22°C | up | 70 | yes | A7; endpoint: activity index; similar results at A3 and for the thrashing rate; similar changes in a rotenone-induced PD model | down | yes | A7; no significant change at A3; similar changes in a rotenone-induced PD model | down | -18 | yes | A12; similar results at A3 & A7 | Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. | no | |||||||||||||||||||||||||||||
250 µg/ml | whole life; start: L4 | OP50 | NGM agar | FUdR | UA44 {baIn11 [dat-1p::α-synuclein, dat-1p::GFP]} | 22°C | up | yes | A12; no significant changes at A3 & A7 | up | yes | A7; endpoint: wave initiation rate; similar results at A3; no significant changes for the activity index | down | no | A3 & A7 | Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. | no |