Compound ID 195   (prev - next)

Name: Hidrox® (edit)

8 entries:
TreatmentHidrox®cognitive functionphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLneuronal survival / integritylocomotion in liquid mediabody wave numberheat stress resistancequantity of α-synucleinautofluorescence (age pigment / lipofuscin)mean lifespanmaximum lifespanmedian lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperaturechange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)notes
100 µg/mlwhole life; start: L4OP50NGM agarFUdRN2 (wild type)22°CupyesA3; stressor: 37°C for 3h; endpoint: mean survivalupupDi Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. no
250 µg/mlwhole life; start: L4OP50NGM agarFUdRN2 (wild type)22°Cup48yesA12; endpoint: activity index; similar changes at A3 and A7 and for the wave initiation rate at all agesdown-27yesA3, A7 & A12up40yesA3; stressor: 37°C for 3h; endpoint: mean survivaldown-3yesA12; no significant changes at A3 & A7; red fluorescenceup12yesup7noup16yesDi Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. no
500 µg/mlwhole life; start: L4OP50NGM agarFUdRN2 (wild type)22°CupyesA3; stressor: 37°C for 3h; endpoint: mean survivalupDi Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. no
250 µg/mlwhole life; start: L4OP50NGM agarFUdROW13 {grk-1(ok1239); pkIs2386 [unc-54p:: α-synuclein::YFP + unc-119(+)]}22°Cup70yesA7; endpoint: activity index; similar results at A3 and for the thrashing rate; similar changes in a rotenone-induced PD modeldownyesA7; no significant change at A3; similar changes in a rotenone-induced PD modeldown-18yesA12; similar results at A3 & A7Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. no
250 µg/mlwhole life; start: L4OP50NGM agarFUdRUA44 {baIn11 [dat-1p::α-synuclein, dat-1p::GFP]}22°CupyesA12; no significant changes at A3 & A7upyesA7; endpoint: wave initiation rate; similar results at A3; no significant changes for the activity indexdownnoA3 & A7Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, Schmitz-Linneweber C, Calabrese V, Saul N (2020) Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models. Int J Mol Sci 21, 3893. no