Compound ID 200 (prev - next)

Name: Icariin (5318997) (edit)

9 entries:

Treatment	Icariin						physical function				physiological function				lifespan				Reference
CID (PubChem)	5318997	ChEMBL					locomotion on solid media				heat stress resistance				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
15 µM	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizone, FUDR	N2 (wild type)	25°C					up		yes	A4; stressor: 35°C; endpoint: survival; test was performed in NGM	up	8.47	variable		Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
45 µM	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizone, FUDR	N2 (wild type)	25°C					up		yes	A4; stressor: 35°C; endpoint: survival; test was performed in NGM	up	24.00	yes		Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
75 µM	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizone, FUDR	N2 (wild type)	25°C									up	8.46	no		Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µM	whole life; start: L4	OP50	NGM agar		AM140 {rmIs132 [unc-54p::Q35::YFP]}	20°C	up		yes	daily monitoring; ratio of non-paralyzed and paralyzed nematodes									Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µM	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizone, FUDR	CB1370 [daf-2(e1370)]										down	-0.17	no		Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µM	whole life; start: A1	OP50	liquid S-medium	carbenicillin, fungizone, FUDR	CF1038 [daf-16(mu86)]	20°C									up	1.86	no		Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.