| Treatment | Icariside I | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 5745470 | ChEMBL | mean lifespan | |||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | N2 (wild type) | 25°C | up | 5.18 | no | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | ||||||