Compound ID 202   (prev - next)

Name: Icariside II (5488822) (edit)

17 entries:
TreatmentIcariside IIphysical functionphysiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)5488822ChEMBLlocomotion in liquid medialocomotion on solid mediaheat stress resistanceoxidative stress resistanceactivity / quantity / expression of SODsquantity of polyQ aggregatesmuscle integritymean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
10 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRN2 (wild type)25°Cup66.23yesA10; endpoint: number of body bends; no significant change in A4up5.20noCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRN2 (wild type)25°Cup16.49yesA4; stressor: 35°C; endpoint: survival; test was performed in NGMup74.07yesA4; stressor: 10 mM hydrogen peroxide for 2 h; endpoint: survival; test was performed in NGM; similar change with 15 mM H2O2; no significant change with 20 mM H2O2up24.82yesA4: up-regulation of sod-3 and hsp-12.3insulin/IGF-1 signaling, HSF-1Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
40 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRN2 (wild type)25°Cup12.70noCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
200 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRN2 (wild type)25°Cup17.70noCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRPD4251 {dpy-20(e1282); ccIs4251 [(pSAK2) myo-3p::GFP::LacZ::NLS + (pSAK4) myo-3p::mitochondrial GFP + dpy-20(+)]}20°CupyesA4 and A10Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: L4OP50NGM agarAM140 {rmIs132 [unc-54p::Q35::YFP]}20°Cupyesdaily monitoring; ratio of non-paralyzed and paralyzed nematodesdownyesA4 and A6Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: L3OP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}25°Cupyes30 h, 33 h, and 35 h after L3; ratio of non-paralyzed and paralyzed nematodesCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: egg stageOP50NGM agarCL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}25°Cupyes30 h, 33 h, and 35 h after L3; ratio of non-paralyzed and paralyzed nematodesCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRCB1370 [daf-2(e1370)]25°Cdown-0.8noCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRCF1038 [daf-16(mu86)]25°Cdown-2.43noCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA4; sod-3 expression; measured via western blotCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRDA1116 [eat-2(ad1116)]20°Cup14.90yesCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRPS3551 [hsf-1(sy441)]25°Cup0.85noCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.
20 µMwhole life; start: A1OP50liquid S-mediumcarbenicillin, fungizone, FUDRXA8223 [rsks-1(ok1255)]20°Cup18.60yesCai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835.