Treatment | Icariside II | physical function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | 5488822 | ChEMBL | | | | | locomotion in liquid media | | | | locomotion on solid media | | | | heat stress resistance | | | | oxidative stress resistance | | | | activity / quantity / expression of SODs | | | | quantity of polyQ aggregates | | | | muscle integrity | | | | mean lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
10 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | N2 (wild type) | 25°C | up | 66.23 | yes | A10; endpoint: number of body bends; no significant change in A4 | | | | | | | | | | | | | | | | | | | | | | | | | up | 5.20 | no | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | N2 (wild type) | 25°C | | | | | | | | | up | 16.49 | yes | A4; stressor: 35°C; endpoint: survival; test was performed in NGM | up | 74.07 | yes | A4; stressor: 10 mM hydrogen peroxide for 2 h; endpoint: survival; test was performed in NGM; similar change with 15 mM H2O2; no significant change with 20 mM H2O2 | | | | | | | | | | | | | up | 24.82 | yes | | A4: up-regulation of sod-3 and hsp-12.3 | | | insulin/IGF-1 signaling, HSF-1 | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
40 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 12.70 | no | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
200 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | N2 (wild type) | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 17.70 | no | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | PD4251 {dpy-20(e1282); ccIs4251 [(pSAK2) myo-3p::GFP::LacZ::NLS + (pSAK4) myo-3p::mitochondrial GFP + dpy-20(+)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | up | | yes | A4 and A10 | | | | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: L4 | OP50 | NGM agar | | AM140 {rmIs132 [unc-54p::Q35::YFP]} | 20°C | | | | | up | | yes | daily monitoring; ratio of non-paralyzed and paralyzed nematodes | | | | | | | | | | | | | down | | yes | A4 and A6 | | | | | | | | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: L3 | OP50 | NGM agar | | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 25°C | | | | | up | | yes | 30 h, 33 h, and 35 h after L3; ratio of non-paralyzed and paralyzed nematodes | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: egg stage | OP50 | NGM agar | | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 25°C | | | | | up | | yes | 30 h, 33 h, and 35 h after L3; ratio of non-paralyzed and paralyzed nematodes | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | CB1370 [daf-2(e1370)] | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -0.8 | no | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | CF1038 [daf-16(mu86)] | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -2.43 | no | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | up | | yes | A4; sod-3 expression; measured via western blot | | | | | | | | | | | | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | DA1116 [eat-2(ad1116)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 14.90 | yes | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | PS3551 [hsf-1(sy441)] | 25°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 0.85 | no | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |
20 µM | whole life; start: A1 | OP50 | liquid S-medium | carbenicillin, fungizone, FUDR | XA8223 [rsks-1(ok1255)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 18.60 | yes | | | | | | Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY (2011) Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6, e28835. | |