Compound ID 207 (prev - next)

Name: Isoxanthohumol (513197) (edit)

17 entries:

Treatment	Isoxanthohumol						physiological function				healthspan biomarkers								lifespan								Target	Reference
CID (PubChem)	513197	ChEMBL					heat stress resistance				ROS level				translocation of DAF-16 to nucleus				median lifespan				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
10 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	N2 (wild type)	20°C	none		no	A3; stressor: 37°C; endpoint: mean and median lifespan	none		no	A3; pre-exposed to 37°C; measured via H2DCF-DA														Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
50 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	N2 (wild type)	20°C	up	8.70	no	A3; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespan	none		no	A3; pre-exposed to 37°C; measured via H2DCF-DA														Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
100 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	N2 (wild type)	20°C	up	13.04	yes	A3; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespan	down	-23.90	yes	A3; pre-exposed to 37°C; measured via H2DCF-DA													DAF-16	Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
200 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	N2 (wild type)	20°C	up	34.78	yes	A3; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespan																		Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
10 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	CF1038 [daf-16(mu86)]	20°C					none		no	A3; pre-exposed to 37°C; measured via H2DCF-DA														Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
50 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	CF1038 [daf-16(mu86)]	20°C					none		no	A3; pre-exposed to 37°C; measured via H2DCF-DA														Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
100 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	CF1038 [daf-16(mu86)]	20°C	none		no	A3; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespan	up	23.80	yes	A3; pre-exposed to 37°C; measured via H2DCF-DA														Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
200 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	CF1038 [daf-16(mu86)]	20°C	none		no	A3; stressor: 37°C; endpoint: mean lifespan; similar change in median lifespan																		Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
100 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA, FUDR	N2 (wild type)	20°C													none				up	2.43	no			Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
200 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA, FUDR	N2 (wild type)	20°C													none				down	-2.08	no			Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
100 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA, FUDR	CF1038 [daf-16(mu86)]	20°C													none				down	-0.52	no			Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
200 µM	whole life; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA, FUDR	CF1038 [daf-16(mu86)]	20°C													none				down	-4.71	yes			Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
100 µM	1 h; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C									up		yes											Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.
200 µM	1 h; start: L4/A1	OP50-1	liquid S-medium	streptomycin, BSA	TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}	20°C									up		yes											Büchter C, Havermann S, Koch K, Wätjen W (2016) Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr 55, 257-265.