Compound ID 21 (prev - next)

Name: 2,3-Dehydrosilybin A/B (edit)

12 entries:

Treatment	2,3-Dehydrosilybin A/B						physical function												reproductive function																physiological function				healthspan biomarkers																				lifespan				Target	Reference
CID (PubChem)		ChEMBL					pharyngeal pumping				locomotion on solid media				duration of defecation cycles				number of offspring				quantity of embryonic lethality				quantity of dauer formation				speed of larval development				oxidative stress resistance				quantity of β-Amyloid				activity / quantity / expression of SODs				activity / quantity / expression of CTLs				quantity of carbonylated proteins				triglyceride / fat / lipid content				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
5 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C																																																					up	2.16	yes			Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
10 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C	up	7.04	yes	A1					up	4.62	yes	A1	down	-4.32	no		up	32.75	no		down	-40.06	no	eggs were exposed to 27°C	down	-0.38	no		up		yes	A1; stressor: 80 µM juglone for 15 min; endpoint: survival					up		yes	A1	up		yes	A1	down		yes		up		yes	A1	up	10.15	yes		FGT-1, DAF-16	Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
10 µM	whole life; start: parental generation	HT115 (DE3)	NGM agar	IPTG	N2 (wild type)	20°C	up	14.78	yes	A1																																																	up	1.18	yes			Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
20 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C																																																					up	2.16	no			Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
10 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		DR26 [daf-16(m26)]	20°C	down	-2.90	no	A1																																	none		no	A1	none		no	A1									none		no			Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
10 µM	whole life; start: parental generation	HT115 (DE3) with RNAi-vector against fgt-1	NGM agar	IPTG	N2 (wild type)	20°C	up	1.45	no	A1																																																	up	5.45	no			Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
10 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar	phloretin	N2 (wild type)	20°C																																																					none		no			Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
10 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		CL2331 {dvIs37 [myo-3p::GFP::A-Beta (3-42) + rol-6(su1006)]}	16°C																																	down		yes	A2; total and oligomeric Aβ species																						Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.
10 µM	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		GMC101 {dvIs100 [unc-54p::A-beta-1-42::unc-54 3'-UTR + mtl-2p::GFP]}	20°C					up		yes	A1/A2; pre-exposure to 25°C for 16°C; endpoint: number of paralyzed and non-paralyzed worms																																																		Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N (2017) 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radic Biol Med 103, 256-267.