| Treatment | L-Ascorbic acid (Vitamin C) | physiological function | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 54670067 | ChEMBL | CHEMBL196 | oxidative stress resistance | ROS level | activity / quantity / expression of HSPs | ||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 100 µg/ml | whole life; start: L1 | OP50 | NGM agar | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | down | -31.00 | yes | A1 | down | no | A1; measured by fluorescence intensity after oxidative stress (40 µM juglone for 24 h) | Strayer A, Wu Z, Christen Y, Link CD, Luo Y (2003) Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. FASEB J 17, 2305-2307. | |||||||||||
| 0.1 µg/ml | whole life; start: L1 | OP50 | NGM agar | N2 (wild type) | 20°C | up | 36.4 | yes | Llopis S, Rodrigo MJ, González N, Genovés S, Zacarías L, Ramón D, Martorell P (2019) β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model. Nutrients 11, 232. | no | ||||||||||||||