| Treatment | L-Dopa | healthspan biomarkers | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 6047 | chEMBL | quantity of α-synuclein | |||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 5 µM | whole life; start: L1 | OP50 | liquid S-medium | NL5901 {pkIs2386 [unc-54p::alphasynuclein::YFP + unc-119(+)]} | 20°C | down | -15 | yes | L4 | Wei, C. C., Chang, C. H., & Liao, V. H. C. (2017). Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans. Phytomedicine, 36, 118-125. | ||||||