Compound ID 219 (prev - next)

Name: LY294002 (3973) (edit)

12 entries:

Treatment	LY294002						physical function								reproductive function				physiological function				lifespan				Target	Reference
CID (PubChem)	3973	ChEMBL					pharyngeal pumping				locomotion on solid media				quantity of dauer formation				heat stress resistance				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
0.8 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20 °C									none		n.d.		up	23,49	yes	A1; Stressor: 35°C					PI3K, age-1	Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 20, 513-519.
16 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20 °C									up		n.d.		up	19,68	yes	A1; Stressor: 35°C	up	9.09	yes		PI3K, age-1	Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 20, 513-519.
163 µM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20 °C									up		n.d.		up	16,09	yes	A1; Stressor: 35°C	up	25.00	yes		PI3K, age-1	Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 20, 513-519.
1.6 mM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20 °C									up		n.d.		up	22,39	yes	A1; Stressor: 35°C	up	8.70	no		PI3K, age-1	Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 20, 513-519.
2.4 mM	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20 °C									up		n.d.		up	18,12	yes	A1; Stressor: 35°C	none				PI3K, age-1	Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 20, 513-519.
1.6 mM	whole life; start: L4	OP50	NGM agar		TJ1052 [age-1(hx546)]	20 °C																	up	6.25	yes			Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 20, 513-519.
2.4 mM	whole life; start: L4	OP50	NGM agar		TJ1052 [age-1(hx546)]	20 °C																	up	19.35	yes			Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ (1999) P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 20, 513-519.
100 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	N2 (wild type)	20°C	up	33.91	yes	A10; unchanged at A1, A5, and A15	down		no	A5; unchanged at A1; variable at A10 and A15; endpoint: number of body bends									up	20.87	yes			Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.
100 µM	whole life; start: L4	OP50, ethanol- and UV-inactivated	NGM agar	FUDR	DA465[eat-2(ad465)]	20°C																	up	5.26	no			Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhães JP (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15, 256-266.