Treatment | Lappaol C | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 323896 | ChEMBL | oxidative stress resistance | ROS level | activity / quantity / expression of HSPs | translocation of DAF-16 to nucleus | mean lifespan | |||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
10 µM | whole life; start: unknown | OP50 | NGM agar | N2 (wild type) | 20°C | down | -16.71 | yes | Treatment for 72 h (start of treatment unknown); measurement via H2DCF-DA | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | ||||||||||||||||||||||
100 µM | whole life; start: unknown | OP50 | NGM agar | N2 (wild type) | 20°C | down | no | Treatment for 72 h (start of treatment unknown); measurement via H2DCF-DA | up-regulation of daf-16 and jnk-1 | jnk-1 and daf-16 | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||
200 µM | whole life; start: unknown | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | Treatment for 72 h (start of treatment unknown); measurement via H2DCF-DA | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||||
10 µM | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | up | 11.30 | yes | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||||
100 µM | whole life; start: A1 | OP50 | NGM agar | N2 (wild type) | 20°C | up | 11.50 | yes | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||||
50 µM | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | A2; stressor: 80 µM juglone for 24 h; endpoint: survival | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||||
100 µM | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | up | 54.81 | yes | A2; stressor: 80 µM juglone for 24 h; endpoint: survival | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | ||||||||||||||||||||||
200 µM | whole life; start: L4 | OP50 | NGM agar | N2 (wild type) | 20°C | none | no | A2; stressor: 80 µM juglone for 24 h; endpoint: survival | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||||
100 µM | 48 h; start: unknown | OP50 | NGM agar | TJ375 {gpIs1 [hsp-16.2p::GFP]} | 20°C | down | -26.39 | yes | pre-treated with 20 µM juglone for 24h; measured via fluorescence | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | ||||||||||||||||||||||
100 µM | whole life; start: L1 | OP50 | NGM agar | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | yes | A1 | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||||
100 µM | whole life; start: A1 | OP50 | NGM agar | GR1307 [daf-16(mgDf50)] | 20°C | down | -5.70 | no | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. | |||||||||||||||||||||||
100 µM | whole life; start: A1 | OP50 | NGM agar | TK22 [mev-1(kn1)] | 20°C | up | 3.20 | no | Su S, Wink M (2015) Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochemistry 117, 340-50. |