Treatment | Lithium chloride | physical function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CID (PubChem) | 433294 | ChEMBL | locomotion on solid media | mitochondrial DNA copy number | ATP level | quantity of carbonylated proteins | level of autophagy | mean lifespan | maximum lifespan | |||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
10 mM | whole life; start: A1 | OP50-1 | NGM agar | streptomycin | JK1107 [glp-1(q224)] | 25.5°C | up | A7, A9, A15, and A22 | variable | yes | increased in A2 (+12%); decreased in A6 (-13%) and A12 (-31%) | up | yes | A6 (+ 72%) and A12 (+53%); unchanged in A2 | up | no | A2, A6, and A12 | up | 10.94 | yes | no significant change in mortality rate doubling time | none | n.d. | Tam ZY, Gruber J, Ng LF, Halliwell B, Gunawan R (2014) Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 69, 810-820. | ||||||||||||||||
10 mM | 12-24 h; start: L4 | OP50-1 | NGM agar | streptomycin | DA2123 {adls2122 [lgg-1p::GFP::lgg-1 + rol-6(su1006)]} | 20°C | up | yes | A1 | Tam ZY, Gruber J, Ng LF, Halliwell B, Gunawan R (2014) Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 69, 810-820. |