Compound ID 224   (prev - next)

Name: Lithium chloride (433294) (edit)

5 entries:
TreatmentLithium chloridephysical functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)433294ChEMBLlocomotion on solid mediamitochondrial DNA copy numberATP levelquantity of carbonylated proteinslevel of autophagymean lifespanmaximum lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
10 mMwhole life; start: A1OP50-1NGM agarstreptomycinJK1107 [glp-1(q224)]25.5°CupA7, A9, A15, and A22variableyesincreased in A2 (+12%); decreased in A6 (-13%) and A12 (-31%)upyesA6 (+ 72%) and A12 (+53%); unchanged in A2upnoA2, A6, and A12up10.94yesno significant change in mortality rate doubling timenonen.d.Tam ZY, Gruber J, Ng LF, Halliwell B, Gunawan R (2014) Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 69, 810-820.
10 mM12-24 h; start: L4OP50-1NGM agarstreptomycinDA2123 {adls2122 [lgg-1p::GFP::lgg-1 + rol-6(su1006)]}20°CupyesA1Tam ZY, Gruber J, Ng LF, Halliwell B, Gunawan R (2014) Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 69, 810-820.