Compound ID 225 (prev - next)

Name: Liuwei dihuang wan (ethanol extract) (edit)

11 entries:

Treatment	Liuwei dihuang wan (ethanol extract)						physical function				physiological function				healthspan biomarkers																lifespan								Transcriptome	Target	Reference
CID (PubChem)		ChEMBL					locomotion on solid media				oxidative stress resistance				quantity of β-Amyloid				ROS level				activity / quantity / expression of HSPs				activity / quantity / expression of SODs				mean lifespan				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
0.1 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C	down		no	L3; temperature shift to 23°C prior analysing beta-amyloid induced paralysis																					up	8	yes		up	5	n.d.				Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
0.5 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C	up	20	yes	L3; temperature shift to 23°C prior analysing beta-amyloid induced paralysis; percentual change represents onset of paralysis									down		yes	A1; temperature shift to 23°C 30h prior measurement																	A1: up-regulation of hsp-16.2; exposure to 23°C for 10h or 15h prior sampling	HSP-16.2	Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
1 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C	up	20	yes	L3; temperature shift to 23°C prior analysing beta-amyloid induced paralysis; percentual change represents onset of paralysis																															Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
2 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]}	16°C	up	20	yes	L3; temperature shift to 23°C prior analysing beta-amyloid induced paralysis; percentual change represents onset of paralysis; no differences of beta-amyloid accumulation in western blot analysis																															Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
0.5 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	CL2006 {dvIs2 [pCL12(unc-54/human Abeta peptide 1-42 minigene) + pRF4]}	20°C									down		yes	A4; no significant changes at A8																							Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
0.5 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	N2 (wild type)	20°C					up	40	yes	L4; stressor: 300 µM juglone; endpoint: survival																											Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
0.5 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	TJ375 {gpIs1 [hsp-16.2p::GFP]}	20°C																	up		yes	A1, A2, A3; exposure to 35°C for 2h at L4															Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).
0.5 mg/ml	whole life; start: egg stage	OP50	NGM agar	Gentamycin	CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}	20°C																					up		no	A1; with and without exposure to 100 µM juglone at L4 over night											Sangha, J. S., Sun, X., Wally, O. S., Zhang, K., Ji, X., Wang, Z., ... & Zhang, J. (2012). Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One, 7(8).