| Treatment | Lonidamine | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | 39562 | ChEMBL | oxidative stress resistance | mitochondrial ROS production | oxygen consumption rate (OCR) | median lifespan | maximum lifespan | |||||||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 5 µM | whole life; start: L4 | OP50, heat-inactivated | NGM agar | ampicillin | N2 (wild type) | 20°C | up | yes | A6; stressor: 10 mM paraquat; endpoint: survival | up | yes | A5 | variable | yes | decreased respiration after 2 h and 6 h; increased respiration after 120 h; no significant change after 24 h, 48 h, and 72 h | up | 7.80 | yes | up | 7.94 | n.d. | up-regulation of phosphorylated pmk-1 | pmk-1 | Schmeisser S, Zarse K, Ristow M (2011) Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. Horm Metab Res 43, 687-692. doi: 10.1055/s-0031-1286308. | ||||||||
| 5 µM | whole life; start: L4 | OP50, heat-inactivated | NGM agar | N -acetyl- L -cysteine, ampicillin | N2 (wild type) | 20°C | up | 1.90 | no | none | n.d. | Schmeisser S, Zarse K, Ristow M (2011) Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. Horm Metab Res 43, 687-692. doi: 10.1055/s-0031-1286308. | ||||||||||||||||||||
| 5 µM | whole life; start: L4 | OP50, heat-inactivated | NGM agar | ampicillin | KU25 [pmk-1(km25)] | 20°C | down | -0.90 | no | up | 0.62 | n.d. | Schmeisser S, Zarse K, Ristow M (2011) Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. Horm Metab Res 43, 687-692. doi: 10.1055/s-0031-1286308. | |||||||||||||||||||