Compound ID 232 (prev - next)

Name: MAHMA NONOate (NO donor) (135487863) (edit)

19 entries:

Treatment	MAHMA NONOate (NO donor)						physiological function				healthspan biomarkers								lifespan				Transcriptome	Target	Reference
CID (PubChem)	135487863	ChEMBL					heat stress resistance				activity / quantity / expression of HSPs				activity / quantity / expression of HSPs				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
1 mM	3 times at L4, A2 and A4	OP50	NGM agar		N2 (wild type)	20°C													up	14.13	yes			hsf-1, daf-16, mtl-1, ctl-2, gei-7, nlp-29, T19B10.2, and hsp's	Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	once at L4	OP50	NGM agar		N2 (wild type)	20°C	up	22.09	yes	L4; stressor: 34°C after 4h of recovery; similar result after 15h recovery, endpoint: survival													RNA-seq revealed 65 genes induced by NO, like mtl-1, ctl-2,gei-7, nlp-29, T19B10.2, and several hsp's		Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	3 times at L4, A2 and A4	OP50	NGM agar	2% Glucose	N2 (wild type)	20°C													up	18.46	yes				Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	3 times at L4, A2 and A4	OP50	NGM agar		PS3551 [hsf-1(sy441)]	20°C													down	-0.11	no				Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	once at L4	OP50	NGM agar		PS3551 [hsf-1(sy441)]	20°C	none		no	L4; stressor: 34°C after 15h of recovery; endpoint: survival															Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	3 times at L4, A2 and A4	OP50	NGM agar	2% Glucose	PS3551 [hsf-1(sy441)]	20°C													down	-2.5	no				Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	3 times at L4, A2 and A4	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C													down	-2.43	no				Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	once at L4	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C	down	-16.37	no	L4; stressor: 34°C after 4h of recovery; significantly improved survival (+ 08.08 %) after 15h recovery; endpoint: survival															Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	3 times at L4, A2 and A4	OP50	NGM agar		MQ130 [clk-1(qm30)]	20°C													up	13.55	yes				Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	once at L4	OP50	NGM agar		TJ375 {gpIs1 [hsp-16.2p::GFP]}	20°C					up		n.d.	L4, A1, and A2; measured via fluorescence											Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
0.5 mM	once at L4	OP50	NGM agar		TJ375 {gpIs1 [hsp-16.2p::GFP]}	20°C					none		n.d.	L4, A1, and A2; measured via fluorescence											Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
0.25 mM	once at L4	OP50	NGM agar		TJ375 {gpIs1 [hsp-16.2p::GFP]}	20°C					none		n.d.	L4, A1, and A2; measured via fluorescence											Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	once at L4	OP50	NGM agar		AM446 {rmIs223 [C12C8.1::GFP]}	20°C									up		n.d.	A1; measured via fluorescence							Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	2 times at L4 and A2	B.subtilis Δnos	NGM agar	2%glucose, 0.5 mM arginine	N2 (wild type)	20°C	up	57.83	yes	A3; stressor: 34°C; endpoint: survival															Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	once at L4	OP50	NGM agar		OH8 [ttx-3(mg158)]	20°C	up	13.68	yes	L4; stressor: 34°C after 15h of recovery; endpoint: survival															Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.
1 mM	once at L4	OP50	NGM agar		IK597 [gcy-23(nj37); gcy-8(oy44); gcy-18(nj38)]	20°C	up	11.56	yes	L4; stressor: 34°C after 15h of recovery; endpoint: survival															Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E (2013) Bacterial nitric oxide extends the lifespan of C. elegans. Cell 152, 818-830.