Compound ID 237 (prev - next)

Name: Methyl 7-Oxo-7H-pyrido[1, 2, 3-cd]perimidine-9-caboxylate (edit)

7 entries:

Treatment	Methyl 7-Oxo-7H-pyrido[1, 2, 3-cd]perimidine-9-caboxylate						physiological function								healthspan biomarkers				lifespan				Reference
CID (PubChem)		ChEMBL					heat stress resistance				oxidative stress resistance				concentration of N(6)-Carboxymethyllysine (CML)				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
25 nM	whole life; start: unknown	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A7; stressor: 35°C for 16 h; endpoint: survival	up		yes	A7; stressor: 40 mM paraquat for 20 h; endpoint: survival	down		yes	A7; measured via immunosorbent assay	up		yes		Sayed AA, El-Shaieb KM, Mourad AF (2012) Life span extension of Caenorhabditis elegans by novel pyridoperimidine derivative. Arch Pharm Res. 2012 Jan;35(1):69-76.
50 nM	whole life; start: unknown	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A7; stressor: 35°C for 16 h; endpoint: survival	up		yes	A7; stressor: 40 mM paraquat for 20 h; endpoint: survival	down		yes	A7; measured via immunosorbent assay	up		yes		Sayed AA, El-Shaieb KM, Mourad AF (2012) Life span extension of Caenorhabditis elegans by novel pyridoperimidine derivative. Arch Pharm Res. 2012 Jan;35(1):69-76.
100 nM	whole life; start: unknown	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A7; stressor: 35°C for 16 h; endpoint: survival	up		yes	A7; stressor: 40 mM paraquat for 20 h; endpoint: survival	down		yes	A7; measured via immunosorbent assay	up		yes		Sayed AA, El-Shaieb KM, Mourad AF (2012) Life span extension of Caenorhabditis elegans by novel pyridoperimidine derivative. Arch Pharm Res. 2012 Jan;35(1):69-76.
500 nM	whole life; start: unknown	OP50	NGM agar	FUDR	N2 (wild type)	20°C	up		yes	A7; stressor: 35°C for 16 h; endpoint: survival	up		yes	A7; stressor: 40 mM paraquat for 20 h; endpoint: survival	down		yes	A7; measured via immunosorbent assay	up		yes		Sayed AA, El-Shaieb KM, Mourad AF (2012) Life span extension of Caenorhabditis elegans by novel pyridoperimidine derivative. Arch Pharm Res. 2012 Jan;35(1):69-76.