Compound ID 241   (prev - next)

Name: Mitraphylline (edit)

6 entries:
TreatmentMitraphyllinephysiological functionhealthspan biomarkersTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLoxidative stress resistanceROS level
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperaturechange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)notes
1 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CnonenoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratedownnoA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
2 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CnonenoA2; stressor: 80 µM juglone for 24h starting at A1; endpoint: survival ratenonenoA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no
10 µg/mlwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupnoA1; measured via H2DCF-DAAzevedo BC, Roxo M, Borges MC, Peixoto H, Crevelin EJ, Bertoni BW, Contini SHT, Lopes AA, França SC, Pereira AMS, Wink M (2019) Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans. Molecules 24, 3299. no