Compound ID 244   (prev - next)

Name: Monascin (from red mold dioscorea) (12118082) (edit)

12 entries:
TreatmentMonascin (from red mold dioscorea)physiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)12118082ChEMBLheat stress resistanceoxidative stress resistanceactivity / quantity / expression of HSPsactivity / quantity / expression of SODsactivity / quantity / expression of GSTstranslocation of DAF-16 to nucleusmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
1 µMwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupyesA1; stressor: 35°C for 7 h; endpoint: survivalupyesA1; stressor: 250 μM juglone for 2.5 h; endpoint: survivalDAF-16Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
10 µMwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupyesA1; stressor: 35°C for 7 h; endpoint: survivalnonenoA1; stressor: 250 μM juglone for 2.5 h; endpoint: survivalShi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
50 µMwhole life; start: L1OP50liquid S-mediumN2 (wild type)20°CupyesA1; stressor: 35°C for 7 h; endpoint: survivalnonenoA1; stressor: 250 μM juglone for 2.5 h; endpoint: survivalShi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
1 µMwhole life; start: L1OP50NGM agar50 mM glucoseN2 (wild type)20°Cupyesadditionally exposed to 100 µM juglone from A6Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
1 µMwhole life; start: L1OP50liquid S-mediumGR1307 [daf-16(mgDf50)]20°CnonenoA1; stressor: 250 μM juglone for 3 h; endpoint: survivalShi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
1 µMwhole life; start: L1OP50liquid S-mediumCL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}20°Cup27.00yesA1; pre-exposure to 35°C for 2 hShi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
1 µMwhole life; start: L1OP50liquid S-mediumCF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]}20°CupyesA1; sod-3 expression; pre-exposure to 150 μM juglone for 1 h; measured via fluorescenceShi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
1 µMwhole life; start: L1OP50liquid S-mediumCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CupyesA1; gst-4 expression; pre-exposure to 150 μM juglone for 1 h; measured via fluorescenceShi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.
1 µMwhole life; start: L1OP50liquid S-mediumTJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]}20°CupyesA1; similar change with pre-exposure to 50 μM juglone and withoutShi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117.