Treatment | Monascin (from red mold dioscorea) | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||||||||||||||||||
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CID (PubChem) | 12118082 | ChEMBL | heat stress resistance | oxidative stress resistance | activity / quantity / expression of HSPs | activity / quantity / expression of SODs | activity / quantity / expression of GSTs | translocation of DAF-16 to nucleus | mean lifespan | |||||||||||||||||||||||||||||||
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
1 µM | whole life; start: L1 | OP50 | liquid S-medium | N2 (wild type) | 20°C | up | yes | A1; stressor: 35°C for 7 h; endpoint: survival | up | yes | A1; stressor: 250 μM juglone for 2.5 h; endpoint: survival | DAF-16 | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | |||||||||||||||||||||||||||
10 µM | whole life; start: L1 | OP50 | liquid S-medium | N2 (wild type) | 20°C | up | yes | A1; stressor: 35°C for 7 h; endpoint: survival | none | no | A1; stressor: 250 μM juglone for 2.5 h; endpoint: survival | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | ||||||||||||||||||||||||||||
50 µM | whole life; start: L1 | OP50 | liquid S-medium | N2 (wild type) | 20°C | up | yes | A1; stressor: 35°C for 7 h; endpoint: survival | none | no | A1; stressor: 250 μM juglone for 2.5 h; endpoint: survival | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | ||||||||||||||||||||||||||||
1 µM | whole life; start: L1 | OP50 | NGM agar | 50 mM glucose | N2 (wild type) | 20°C | up | yes | additionally exposed to 100 µM juglone from A6 | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | ||||||||||||||||||||||||||||||
1 µM | whole life; start: L1 | OP50 | liquid S-medium | GR1307 [daf-16(mgDf50)] | 20°C | none | no | A1; stressor: 250 μM juglone for 3 h; endpoint: survival | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | |||||||||||||||||||||||||||||||
1 µM | whole life; start: L1 | OP50 | liquid S-medium | CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]} | 20°C | up | 27.00 | yes | A1; pre-exposure to 35°C for 2 h | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | ||||||||||||||||||||||||||||||
1 µM | whole life; start: L1 | OP50 | liquid S-medium | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | up | yes | A1; sod-3 expression; pre-exposure to 150 μM juglone for 1 h; measured via fluorescence | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | |||||||||||||||||||||||||||||||
1 µM | whole life; start: L1 | OP50 | liquid S-medium | CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]} | 20°C | up | yes | A1; gst-4 expression; pre-exposure to 150 μM juglone for 1 h; measured via fluorescence | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. | |||||||||||||||||||||||||||||||
1 µM | whole life; start: L1 | OP50 | liquid S-medium | TJ356 {zIs356 [daf-16p::daf-16a/b::GFP + rol-6(su1006)]} | 20°C | up | yes | A1; similar change with pre-exposure to 50 μM juglone and without | Shi YC, Liao VH, Pan TM (2012) Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 52, 109-117. |